Recent research has illustrated that the intestinal microbiome plays a major role in the development of Type 1 diabetes. Researchers at Mayo Clinic, funded by the Iacocca Foundation and a National Institutes of Health RO1 grant, demonstrated that gluten in the diet may in fact modify the intestinal microbiome, increasing incidences of Type 1 diabetes. The findings were published Nov. 13, in PLOS ONE.

The researchers demonstrated that mice fed a gluten-free diet had a dramatically reduced incidence of Type 1 diabetes. These mice were non-obese diabetic mice, and the gluten-free diet protected the mice against Type 1 diabetes. When the researchers added gluten back into the mice diets, it reversed the protective effect the gluten free diet had provided, and there also was a measurable impact of the gluten on the bacterial flora of the mice that might be one way in which gluten could affect the risk for diabetes.

"These changes suggest that the presence of gluten is directly responsible for the diabetes-creating effects of diet and determines the gut microflora," says Govindarajan Rajagopalan, Ph.D., a Mayo Clinic immunologist and study author.

 

Researchers point out that this research suggests dietary interventions may be crucially important in affecting the likelihood of the development of Type 1 diabetes. "While this is purely an animal-based study, it allows us to manipulate these mice in such a way as to study the effects of certain diets, and these diet changes seem to make an impact on the likelihood of developing the mouse equivalent of type 1 diabetes," says Joseph Murray, M.D., a Mayo Clinic gastroenterologist and study author.

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