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December 15, 2016

This diet’s for you: personalized nutrition to improve your health

By Sharon Rosen
Dr. Heidi Nelson

Dr. Heidi Nelson

You may use the phrase “gut reaction” to describe what your instincts tell you about a particular situation. But it turns out that your gut offers much more than an emotional reaction – it processes food you eat in a way that is unique to you. For example, some people may feel energized and lose weight from eating a high protein and low carbohydrate diet, while others might not get the same benefit from eating the same foods. This occurs because each of us has a unique community of bacteria inside our digestive system, known as the gut microbiome. As a result, we each process the foods we eat differently.

Researchers at Mayo Clinic Center for Individualized Medicine are exploring ways to analyze a person’s gut microbiome and then design a diet to maintain a person’s health and avoid the development of disease.

“We have long wondered why one diet works for one person, but not another. Now, we are beginning to understand that how a person processes food depends upon that individual’s gut microbiome, immune system and the community of bacteria in the gut. This is where the concept of designing individualized diets was developed. Given these multiple factors, we are exploring ways to develop customized diets that will maintain wellness and prevent the development of disease,” explains Heidi Nelson, M.D., director of the Mayo Clinic Center for Individualized Medicine Microbiome Program.

As part of the effort to explore ways individualized diets can be used to improve health, Mayo Clinic is working with DayTwo Inc. to explore the use of microbiome data to advance individualized diet and wellness for patients.

Researchers at DayTwo Inc. completed a study examining the impact of changes in diet on blood glucose levels, which show the level of sugar in the blood. Investigators developed a mathematical model to predict how people’s glucose level would change after eating a variety of foods. Based on that model, they were able to create customized diets appropriate for each person and control glucose levels. Researchers also provided participants with suggested meals, including their top five breakfasts, lunches and dinners, as well as appropriate snacks to maintain their health.

“Glucose levels are abnormally high in patients with diabetes. If we can understand what causes high glucose levels, we may be able to prevent patients from developing prediabetes and type II diabetes. Often traditional interventions to control glucose levels have limited benefit for patients. These study results highlight the important role that personalized diets can play in maintaining better control over blood glucose levels and overall health,” says Dr. Nelson.

Mayo Clinic researchers are working to validate DayTwo’s study at the Weizmann Institute of Science by examining the impact of diet on controlling blood glucose levels. Mayo investigators are also studying the microbiome and different responses to diets in the treatment of obesity, with the plan to develop customized diets for people to someday prevent and/or treat obesity and reduce obesity-related health issues.

Mayo Clinic has a financial interest in DayTwo and will participate in DayTwo’s Series A funding round. Any revenue received will be reinvested in patient care research at Mayo Clinic.

Learn more about the microbiome

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Tags: #blood glucose level, #Center for Individualized Mediicine, #DayTwo, #individualized diets, #medicalresearch, #Microbiome research, #personalized nutrition, #PrecisionMedicine, Diet, Dr. Heidi Nelson, gut bacteria, Gut Microbiome, mayo clinic, Uncategorized

COMMENT

andyw
@andyw

Posts: 2
Joined: Oct 31, 2017
Posted by @andyw, Oct 31, 2017

Anyone who comes across this and looking into it I would recommend proceeding with caution with Day Two or Mayo. I’ve been a part of the research they are doing and was told I’d have a report upon a few weeks of my completion of the study. That was 6+ months ago now and so far nothing. I’m sure it’s good information to have on yourself, but good luck getting it from either of these two places. I would encourage one to look elsewhere.

Susan Buckles
@susanbuckles

Posts: 14
Joined: Jun 08, 2016
Posted by @susanbuckles, Dec 22, 2017

Thank you for commenting. See the reply under your second comment.

andyw
@andyw

Posts: 2
Joined: Oct 31, 2017
Posted by @andyw, Dec 21, 2017

Update: 8+ months out and still nothing of what was promised to me. Ended up sending a complaint to Mayo’s Research Study Advocate group. All that got me was a meeting with excuses and apologies, but no results. Evidently, the only individual Mayo’s Center for Individualized Medicine cares about is Mayo not the patient.

Susan Buckles
@susanbuckles

Posts: 14
Joined: Jun 08, 2016
Posted by @susanbuckles, Dec 22, 2017

The study closed for enrollment in early December. The subjects will begin receiving an email to obtain their results over the next two months, beginning next week.

katdazzle
@katdazzle

Posts: 1
Joined: Jan 18, 2018
Posted by @katdazzle, Thu, Jan 18 4:40am

I received my results from Day Two in only a few weeks and I am very happy with the results! I’m using their very helpful app and I began feeling different by the second day. I was shocked to learn that what I thought was healthy eating since the 1980’s was not healthy for me! I was doubtful and scared to eat what they recommended, but I did and my body told me I was the right thing because I felt great!

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