Share this:
August 31st, 2017

The Grand Challenge: using supercomputers to speed diagnosis and treatment

By Sharon Rosen

If you are a cancer patient who has exhausted all standard treatment options, a one day turnaround of your DNA testing results could make a big difference in your search for new, individualized treatment options. Mayo Clinic envisions just that: using supercomputers that are so fast and efficient they can interpret your DNA sequence in hours so providers can quickly apply them to individualized patient care.

Right now, it can take several days to weeks for computer systems to analyze DNA sequences looking for new treatment options. This is time that many patients with advanced cancer do not have. Researchers at Mayo Clinic Center for Individualized Medicine and the University of Illinois at Urbana-Champaign (Illinois) are collaborating on a research effort known as the Grand Challenge project, employing supercomputers that are many times faster than typical home or business computers so that analysis and interpretation of a complete human genome sequence can be completed in just one day.

The goals of the project are to develop methods within the next two years to automate and speed:

  • Analysis of DNA sequence to identify genetic variations that may be linked to disease – right now it can take days. The goal is to do it in hours.
  • Interpretation of genetic data so massive that it’s like sifting through a huge haystack and finding the needle with the clues to health and disease – right now we only understand the impact of 2 to 3 percent of the genetic variations that are discovered.

Keith Stewart, M.B., Ch.B.

According to Keith Stewart, M.B., Ch.B., the project addresses the need to move genomics from a manual exercise to an automated process that delivers information physicians can use in making a diagnosis or finding precise therapies.

“Eventually we hope to sequence the genome for all Mayo patients, incorporating those results in their electronic health record to inform future medical care.  This would enable us to harness the promise of genomics and better prevent, diagnose, treat and even cure disease,” says Dr. Stewart, Carlson and Nelson Endowed Director, Center for Individualized Medicine, and Vasek and Anna Maria Polak Professor of Cancer Research.

First pilot study – searching for genetic factors linked to a rare congenital heart disease

The research team will start developing and testing new genomic computational models using genomic data from approximately 300 people from families that have been affected with hypoplastic left heart syndrome (HLHS), a rare congenital heart disease, according to Eric Wieben, Ph.D., director, Medical Genome Faculty, and co-director, Clinomics Program, in the Center for Individualized Medicine.

Eric Wieben, Ph.D.

“Thanks to the foresight and effort of Timothy Nelson, M.D., Ph.D., and Timothy Olson, M.D., in the Center for Regenerative Medicine and the support of the Wanek family, we have genomic sequencing data on those affected by HLHS. This defined data set provides an initial testing ground to refine our computer models, before scaling them for larger numbers of patients. We know that HLHS patients and their family members share common underlying genetic characteristics linked to the disease, making them an ideal group to test new analytical models. To date, we have only been able to find genetic factors linked to a few of the HLHS cases. With new sequencing and computational models, we hope to solve that mystery for more families, potentially leading to the development of new targeted treatments for this serious heart condition,” says Dr. Wieben.

Research collaboration key to success

Mathieu Wiepert

Mathieu Wiepert, who provides IT support for the Center for Individualized Medicine and other Mayo research programs, says the Grand Challenge is just one project of the Mayo Clinic & Illinois Alliance for Technology-based Healthcare, a collaboration to develop additional technology and capacity to meet the big data challenge in health care.

“Our collaboration with University of Illinois faculty is critical to solving this and other big data challenges being faced in medicine today. We each have complementary strengths – Mayo with expertise in clinical medicine and genomics and Illinois with expertise in computer science and engineering. By collaborating, we can make a real difference for patients, providing critical answers faster, allowing them to get the care they need sooner,” says Wiepert.

Learn more about ongoing efforts to improve genomic data analysis

Register for the 2017 Individualizing Medicine Conference

Learn more about precision medicine and how that can be applied to improve diagnosis and treatment for many conditions at Individualizing Medicine 2017: Advancing Care Through Genomics.

The Mayo Clinic Center for Individualized Medicine, is hosting the sixth annual genomics conference, October 9–10, in Rochester, Minnesota.

Mayo Clinic Center for Individualized Medicine is hosting the conference with support from the Jackson Family Foundation.

 

 

 

 

Tags: #big data challenges, #CIMCon17, #Dr. Eric Wieben, #Dr. Timothy Nelson, #Dr. Timothy Olson, #genetic data analysis, #Genomic data, #Individualizing Medicine 2017, #Mathieu Wiepert, Big Data, center for individualized medicine, Center for Regenerative Medicine, Dr. Keith Stewart, electronic health record, genomics, individualized medicine, mayo clinic, Precision Medicine, University of Illinois at Urbana-Champaign

Comment


robertjames
@robertjames

Posts: 2
Joined: Sep 12, 2017
Posted by @robertjames, Tue, Sep 12 9:13am

A POWERFUL HSV-2 CURE EVERY SUFFERER NEEDS TO KNOW ABOUT.CONTACT +2348161850195 eromosalespelltemple @ gmail .com

I have been suffering from (HERPES SIMPLEX VIRUS) for the past two years and the pain has been constant especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from my doctor, few weeks ago i came on search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from (HERPES SIMPLEX VIRUS) by this Man Dr Ero and she also gave the email address: eromosalespelltemple @ gmail .com of this man and advise we should contact him for any sickness that he would be of help, so i wrote to Dr. Ero telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as the Dr assured me that i have be cured,after some time i went to my doctor to confirmed if it was true that am finally healed behold it was TRUE, dear friends if you have such virus and you wise to be cure totally then here is the mail to contact:: eromosalespelltemple @ gmail .com or whats App his number on +2348161850195


anniela
@anniela

Posts: 2
Joined: Sep 30, 2017
Posted by @anniela, Sat, Sep 30 12:24pm

My name is Charlie Goddard I am from New York, I’m here to give a

testimony on how I got cure by Dr. Abulu, I was diagnosed with “HERPES”

since 2014, And with the help Dr. Odudu Osun, now I am back alive and

healthy now. Thanks for curing me with your herbal medicine, save

yourself from buying medicine to sustain while you can get a cure,

contact Dr. Abulu Osun via email (abuluherbalcure@gmail.com or call him

+2349025278319. ALSO HAVE THIS CURE HERPES HSV-1 and HSV-2, KIDNEY

DISEASE, CANCER )


stefenn
@stefenn

Posts: 1
Joined: Mar 05, 2017
Posted by @stefenn, Fri, Oct 6 6:20pm

I am from New York. I was in trouble when doctor told me that I have been diagnosed with Genital Herpes… I though about my Family, I know my Family will face a serious problem when I’m gone, I lost hope and I wept all day, but one day I was surfing the internet I found Dr. idahosa email. I emailed him and he guided me. I asked him for solutions and he started the remedies for my health. Thank God, now everything is fine, I’m cured by Dr. idahosa herbal medicine, I’m very thankful to Dr. idahosa and very happy with my hubby and family. email him on idahosaherbalhome@gmail.com or whatsapp Tel- +2347033330164

DOCTOR IDAHOSA CAN AS WELL CURE THE FOLLOWING DISEASE:-

1. HIV/AIDS
2. HERPES
3. CANCER
4. ALS
5. Arthritis
6. Shingles


anniela
@anniela

Posts: 2
Joined: Sep 30, 2017
Posted by @anniela, Sat, Oct 7 10:09pm

I am from New York. I was in trouble when doctor told me that I have been diagnosed with Genital Herpes… I though about my Family, I know my Family will face a serious problem when I’m gone, I lost hope and I wept all day, but one day I was surfing the internet I found Dr.Abulu email. I emailed him and he guided me. I asked him for solutions and he started the remedies for my health. Thank God, now everything is fine, I’m cured by Dr. Abulu herbal medicine, I’m very thankful to Dr. Abulu and very happy with my hubby and family. email him on abuluherbalcure At gmail.com or whatsapp Tel- +2349025278319

DOCTOR ABULU CAN AS WELL CURE THE FOLLOWING DISEASE:-

1. HIV/AIDS

2. HERPES

3. CANCER

4. ALS

5. Arthritis

6. Shingles


queenbilly
@queenbilly

Posts: 1
Joined: Nov 20, 2017
Posted by @queenbilly, 3 days ago

May God continue to bless Dr Koba for his awesome work he is doing to save many lives, i have been a sufferer of HSV 1&2 disease which i didn’t know how i got it, but when i found out about it 5years ago i have been very angry and stress getting a remedy, and doctors say there is no cure for HSV 1&2 disease, but one wonderful morning i was out searching out for herbal remedy and i saw a comment of someone talking about how Dr Koba has cured them and i to the next page someone else was also talking about Dr Koba, i was relieve and happy that finally i have found someone that has remedy for me, i contacted his Email address:drkobaherbalsolutionhome@gmail.com and before i knew it he replied me and that how i got my herbal medicine and i used it for only 2weeks i was totally cured, i am so happy viewers contact Dr Koba and get your cure now, or what app him:+2349037387574 or contact his website:drkobaherbalsolutionhome.wordpress.com

Please login or register to post a comment.
Contact Us · Privacy Policy