After nearly half a century of research, Mayo Clinic is a leader in moving pharmacogenomics into clinical practice. This year pharmacogenomics test results for 10,000 Mayo Clinic patients, all participants in the RIGHT 10K study, are being added to the electronic health record.
“I’ve spent my career exploring pharmacogenomics - how a person’s genetics affect his or her response to medications. Mayo has been a pioneer in this area of precision medicine. The RIGHT 10K study translates decades of research on drug-gene interactions into pre-emptive patient care. My hope is that within the next five years, genomic test results for the majority of our patients will be part of their electronic health record, allowing physicians to proactively use this information to individualize care,” says Richard Weinshilboum, M.D., co-director of the Mayo Clinic Center for Individualized Medicine Pharmacogenomics Program.
The RIGHT 10K study and the information in the electronic health record have the potential to inform the practice by guiding health care providers in their prescribing. The goal is to understand how genetic testing may help improve health care by identifying medications and/or making dose adjustments that are compatible with a patient’s genetic makeup.
“Medications today can be very effective, but they can also cause harmful, sometimes life-threatening side effects. That’s where pharmacogenomics can help physicians select the right drug and dose for every patient.” - Richard Weinshilboum, M.D.
“Medications today can be very effective, but they can also cause harmful, sometimes life-threatening side effects. That’s where pharmacogenomics can help physicians select the right drug and dose for every patient,” says Dr. Weinshilboum.
On record - genetics data to help select the right drug and dose
Paul Takahashi, M.D., a primary care physician and co-director, Mayo Clinic Biobank, is one of the early pioneer physicians to use this new pharmacogenomics information in his medical practice.
Sixteen of his patients are the first to have their pharmacogenomics data added to their electronic health record.
“We consider many factors when prescribing medications. The pharmacogenomic data will give us another tool to help tailor treatments. I think it will improve the safety and effectiveness of treatments for patients on a variety of medications, including those commonly used to treat pain. It’s a very practical first step for using genomics to individualize patient care.” - Paul Takahashi, M.D.
“We consider many factors when prescribing medications. The pharmacogenomic data will give us another tool to help tailor treatments. I think it will improve the safety and effectiveness of treatments for patients on a variety of medications, including those commonly used to treat pain. It’s a very practical first step for using genomics to individualize patient care,” says Dr. Takahashi.
Advancing discovery and patient care – RIGHT 10K offers a world of opportunities
This RIGHT 10K study builds on Mayo’s leadership in moving pharmacogenomics from research to practice:
“The RIGHT 10K pharmacogenomic test results could help individualize care for virtually every disease – from cancer to heart disease, diabetes and obesity.” - Dr. Weinshilboum
“The RIGHT 10K pharmacogenomic test results could help individualize care for virtually every disease – from cancer to heart disease, diabetes and obesity,” says Dr. Weinshilboum.
The study also offers unlimited opportunities for Mayo physicians and researchers to:
Implementing pharmacogenomics – a team sport
Moving pharmacogenomic data for 10,000 patients into the electronic health record didn’t happen magically – it’s been accomplished by a multidisciplinary team of experts.
As Dr. Weinshilboum explains, “Pharmacogenomics is truly a team sport at Mayo. We’ve reached this milestone with a collaborative team of clinicians, geneticists, pharmacists and information technology specialists, each bringing their expertise to help move pharmacogenomics directly into the clinical practice.”
Mayo Clinic also collaborated with Baylor College of Medicine to sequence DNA from the RIGHT 10K study participants.
To move these data into the practice, the Mayo team developed:
The team’s efforts have the potential to offer far reaching benefits.
“Not only Mayo patients, but patients everywhere will benefit from the lessons we learn from this research. In addition, we’re sharing our unique collaborative research model with physicians around the world who are looking to bring clinical genomics into their medical practices,” says Dr. Weinshilboum.
Mayo Clinic’s pharmacogenomics research efforts have been supported through many grants including the National Institutes of Health (NIH) Pharmacogenomics Research Network and NIH Electronic Medical Records and Genomics (eMERGE) Network.
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Save the date for this year’s Individualizing Medicine Conference. It will be held in Rochester, Minnesota, on Sept. 12-13, 2018.
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