Today marks the 1 year anniversary of the Mayo Clinic Center for Individualized Medicine opening the proverbial doors to begin seeing patients in the Individualized Medicine Clinic (IM Clinic). The opening of the IM Clinic was a collaborative effort across multiple departments across the three campuses of Mayo Clinic. The two Service Lines, Advanced Cancer Patients and Diagnostic Odyssey Patients (those with rare or undiagnosed diseases), have become available at all three campuses over the course of the last year, and a third Service Line is being created to build clinical utility through preventative exome/genome information.
Dr. Gianrico Farrugia, Director of the Mayo Clinic Center for Individualized Medicine, took to the stage this morning to open the Individualized Medicine ...
http://www.youtube.com/watch?v=ub0zFn-iVBU A simple treatment that involves transplanting healthy feces into a patient suffering from a debilitating and sometimes deadly infection of the colon called Clostridium ...
The Individualized Medicine Conference is gearing up for it’s second appearance in Rochester, MN. The conference looks to provide a platform for a discussion on ...
http://www.youtube.com/watch?v=NgMZVbeOLPs&feature=share&list=PLE4A384A799EFD6C4 Individualized health care means better health care. Programs in the Mayo Clinic Center for Individualized Medicine will lead to increased capabilities for doctors ...
http://youtu.be/vWly8cjo-mo Matthew Ferber, Ph.D., Director of Mayo Clinic's Molecular Genetics Laboratory, discusses Mayo Clinic's Hereditary Colon Cancer Multi-Gene Panel, which uses next generation sequencing ...
Novel TRAF1-ALK fusion identified by deep RNA sequencing of anaplastic large cell lymphoma Abstract Chromosomal translocations leading to expression of abnormal fusion proteins play a major role ...
Working in partnership with the Institute for Genomic Biology at the University of Illinois at Urbana-Champaign, the Center for Individualized Medicine and the Bruce Fouke Lab produced a work of art from the photo of a human kidney stone (featured after the break) that was featured at the Chicago Midway International Airport at "The Art of Science: Images from the Institute for Genomic Biology" exhibit.
The most common hereditary colon cancer disorder, Lynch syndrome, increases the risk of colorectal cancer (CRC) and are usually caused by germline mutations in 1 of 4 mismatch repair (MMR) genes: MLH1, MSH2, MSH6 and PMS2. Identifying people who are at risk is important for their care, as well as the care of members of their family. A Lynch diagnosis may determine the extent of colon cancer surgery, for instance, and it increases the need for more-frequent colonoscopies after a colon cancer diagnosis.
Colorectal cancer (CRC) remains the second-leading cause of cancer deaths in the United States, and a new multi-marker test for stool DNA (sDNA) developed by Mayo Clinic in collaboration with Exact Sciences Corp. of Madison, Wis., has seen improvements to the effectiveness of screening for CRC and reducing risk. No special preparations are needed for the test, it can be performed on mailed-in samples. This eliminaties the need for an office visit, and it has provides highly accurate at detecting premalignant polyps and early-stage colorectal cancer. "We have a mandate to improve effectiveness of screening by better use of existing tools and by creating better tools," says David A. Ahlquist, M.D., of Mayo Clinic. "If one had to start all over, the ideal screening test would be noninvasive and affordable; require no bowel prep, medication restriction or diet change; and would detect neoplasms on both sides of the colorectum with high accuracy."
Until recently, polygenic (complex) diseases were beyond the capacity of first-generation sequencing, but next-generation sequencing (NGS) in making exploration of genetic etiology of complex diseases a possibility for the first time. NGS is a rapidly growing area of genomics and gene sequencing, and the rapid changes hold more promise for exome decoding than ever before. "NGS offers rapid sequencing of the entire human genome compared to traditional molecular testing that focuses on a single gene at a time. And it does so at low cost with high accuracy," explains Konstantinos N. Lazaridis, M.D., Enterprise Director of the Individual Medicine Clinic.