Multi-omics

July 20, 2022

2022 Gerstner Awardee to investigate gut microbiome link to chemotherapy-induced nausea

By Susan Murphy Susan Murphy (@susanmurphy)

Dr. Singh is investigating individualized strategies to help mitigate symptoms of chemotherapy-induced nausea in patients receiving chemotherapy for breast cancer. Her research focuses on the complex link between nausea-related symptoms and the gut microbiome — a population of bacteria, viruses, and fungi that inhabit the gastrointestinal tract. 

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Tags: center for individualized medicine, genomic medicine, genomics


July 20, 2022

2022 Gerstner Awardee to investigate dual CAR-T cell therapy for multiple myeloma cancer

By Susan Murphy Susan Murphy (@susanmurphy)

Dr. Sakemura is working to advance immunotherapy efficacy in multiple myeloma cancer by uncovering treatment resistance mechanisms and developing a more potent immunotherapy approach. His strategy focuses on simultaneously targeting cancer cells and the ecosystem surrounding each tumor, known as the tumor microenvironment. 

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Tags: center for individualized medicine, Genetics, genomics, individualized medicine, medical research, Multiple Myeloma


July 15, 2022

BA.5 omicron variant fueling latest COVID-19 surge

By Susan Murphy Susan Murphy (@susanmurphy)

A team of scientists within Mayo Clinic’s COVID-19 Sequencing Command Center is at the forefront of tracing the genetic evolution of SARS-CoV-2, the virus that causes COVID-19. The extensive research and surveillance operation involves conducting hundreds of sequences of the COVID-19 virus each week.

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Tags: center for individualized medicine, covid-19, Genetics, genomics, individualized medicine, medical research


July 6, 2022

Do environmental exposures contribute to human diseases? 

By Susan Murphy Susan Murphy (@susanmurphy)

Mayo Clinic researchers put the exposome under the microscope to understand links between lifelong exposures and diseases.

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Tags: center for individualized medicine, DNA Testing, Dr. Konstantinos Lazaridis, exposome, gene sequencing, Genetics, genomics


June 29, 2022

Mayo study validates threshold to determine when an antidepressant is ineffective

By Susan Murphy Susan Murphy (@susanmurphy)

Mayo Clinic researchers have validated a threshold designed to help determine if an antidepressant used for depression is working, but not well enough to be continued.

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Tags: #Dr. William Bobo, antidepressants, center for individualized medicine, depression, genomics, individualized medicine, major depressive disorder, medical research, personalized medicine


June 21, 2022

Scientists unravel genetic mystery of rare neurodevelopmental disorder, provide definitive diagnoses to 21 families worldwide

By Susan Murphy Susan Murphy (@susanmurphy)

A collaborative team of scientists led by Mayo Clinic’s Center for Individualized Medicine has discovered 15 additional genetic mutations in the KCNK9 gene that cause a neurodevelopmental syndrome. Symptoms of the disorder range from speech and motor impairment to behavioral abnormalities, intellectual disability and distinctive facial features.

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Tags: #neurological disorders, center for individualized medicine, Dr. Margot Cousin, gene sequencing, genomics, medical research, personalized medicine


June 13, 2022

Native American’s genetic test results at Mayo Clinic reveal surprise lineage to ancient tribe   

By Susan Murphy Susan Murphy (@susanmurphy)

Mayo Clinic working to advance health equity among Native Americans, Alaska Natives Schyler Martin, a member of the Munsee Band of Mohicans in Minnesota, was surprised and excited when his recent Mayo Clinic genetic test results revealed he has distinctive DNA lineage to an ancient group of Native Americans known as the Beringians. According to […]

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Tags: center for individualized medicine, DNA Testing, Dr. Konstantinos Lazaridis, Genetic Testing, Genetics, genomic medicine, individualized medicine, medical research, tapestry


June 2, 2022

A new path forward: Hussein

By Robin Huiras-Carlson Robin Huiras-Carlson (@robinh)

For a young child diagnosed with inflammatory bowel disease, an unexpected turn of events led by results of a Mayo Clinic Laboratories test freed him and his family from the bonds of frequent medical visits and expensive treatment, and opened the door to a life unencumbered by illness. From the beginning of Hussein’s life, a […]

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May 26, 2022

Molecular mapping of the heart to predict disease susceptibility

By Susan Buckles Susan Buckles (@susanbuckles)

Vulnerability to heart disease can be projected before symptoms occur, Mayo Clinic discovered in preclinical research. This proof-of-concept study revealed that heart muscle changes indicate who is vulnerable to disease later in life. These changes can be detected from blood samples through comprehensive protein and metabolite profiling. This exploratory mapping, conducted in the Marriott Family […]

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Tags: Cardiovascular Disease, center for individualized medicine, Center for Regenerative Medicine, genomics, Heart Disease, individualized medicine


May 9, 2022

Mayo patient with life-threatening multidrug-resistant infection treated with experimental phage therapy combined with surgery  

By Susan Murphy Susan Murphy (@susanmurphy)

Mark Pearce, 61, was facing a possible limb amputation, even death, when a multidrug-resistant bacterial infection within his prosthetic hip replacement device started raging in his bloodstream. With his fever soaring to more than 105 degrees, Mark was taken by ambulance, that day in spring of 2020, to Mayo Clinic Hospital in Rochester, Minnesota. 

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Tags: #bacterial infections, bacteria, bacteriophage therapy, center for individualized medicine, Dr. Gina Suh, Dr. Mark Pagnano, genomics, individualized medicine, infectious disease, personalized medicine, phage therapy


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