Precision Medicine

April 12, 2021 · Leave a Comment

Study of mouse gut microbiome may provide clues to how cancer develops in humans

By Susan Murphy Susan Murphy (@susanmurphy)

By Joe Dangor A study of the mouse gut microbiome led by researchers from Mayo Clinic may shed light on how cancerous tumors develop and progress in humans. The findings were presented at the 2021 American Association for Cancer Research annual meeting. “There is growing recognition that healthy tissues accumulate cancer-related mutations over time but they don’t necessarily […]

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Tags: cancer, microbiome


April 6, 2021 · Leave a Comment

Mayo researchers reveal gene therapy path for treating children with rare, fatal genetic disease

By Susan Murphy Susan Murphy (@susanmurphy)

A gene therapy strategy developed by Mayo Clinic researchers could offer a potential treatment for a rare and fatal genetic disease that often sickens babies in their first days of life. The disease, propionic acidemia, occurs in 1 in 100,000 live births in the U.S. There is no cure. “As soon as the babies start […]

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Tags: #gene therapy, rare disease


March 29, 2021

Mayo researchers use AI to reveal causes of complex diseases

By Susan Murphy Susan Murphy (@susanmurphy)

Researchers within Mayo Clinic’s Center for Individualized Medicine have developed an artificial intelligence (AI) platform that can uncover causal drivers and relationships embedded within complex biomedical data. Nicholas Chia, Ph.D., John Kalantari, Ph.D., and Kia Khezeli, Ph.D., recently tested their machine-learning framework, called Causal Relation and Inference Search Platform (CRISP) on multiomic colorectal cancer samples […]

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Tags: #algorithm, artificial intelligence, cancer, colon cancer, colorectal cancer, multi-omics, rare disease


March 25, 2021

Mayo Clinic, Thermo Fisher Scientific collaborate to benefit patients

By Susan Murphy Susan Murphy (@susanmurphy)

By: Suzanne Ferguson| ROCHESTER, Minn. ― Mayo Clinic and Thermo Fisher Scientific have joined forces to bring innovative solutions to patients by accelerating clinical validation, and commercialization of selected next-generation sequencing (NGS), mass spectrometry and immunology diagnostic tools. The Advanced Diagnostics Laboratory in One Discovery Square, which is part of the Destination Medical Center initiative, will […]

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Tags: Discovery Square, IndividualizedMedicine, Mayo Clinic Advanced Diagnostic Laboratory


March 23, 2021 · Leave a Comment

Mayo Clinic researchers explore personalized approach to anti-obesity medications

By Colette Gallagher Colette Gallagher (@colettegallagher)

Individualized medicine initiatives mainly focus on rare diseases or cancer. Little has been attempted to individualize treatment for noncommunicable chronic diseases such as obesity — a chronic, relapsing disease, and a primary cause of Type 2 diabetes, fatty liver disease, cardiovascular disease and cancer. There are many obesity interventions, such as diets, devices, surgery and […]

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Tags: Dr. Andres Acosta, journal obesity, mayo clinic, Mayo Clinic Center for Individualized Medicine, obesity, pharmacogenomics, Precision Medicine


March 19, 2021 · Leave a Comment

Lack of diversity in genomic databases may affect therapy selection for minority groups

By Colette Gallagher Colette Gallagher (@colettegallagher)

Low representation of minority groups in public genomic databases may affect therapy selection for Black patients with cancer, according to new Mayo Clinic research published in npj Precision Oncology. The researchers investigated the use of genomic databases and found that tumor mutation burden was significantly inflated in Black patients compared to White patients. As a […]

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Tags: #Dr. Aaron Mansfield, #Dr. Mitesh Borad, #Dr. Yan Asmann, Dr. Alex Adjei, Dr. Leif Bergsagel, mayo clinic


March 18, 2021

New Framework Leads to Surprise in Early Human Development

By Sara Tiner Sara Tiner (@saratiner)

Mayo Clinic and Yale University scientists have developed a minimally invasive process for studying early cell development in a living person. The team reconstructed the cell history of two adult volunteers from just after cell fertilization. They found that in the first cell divide — 29 years earlier for one volunteer and 66 years earlier […]

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Tags: cells, genome, individualized medicine, Research


March 17, 2021 · Leave a Comment

Data show clear benefit from genetic testing before prescribing antiplatelet therapy

By Susan Murphy Susan Murphy (@susanmurphy)

By Terri Malloy Pharmacogenomics is a valuable tool for health care providers to help prescribe the right drug for the right patient to enhance efficacy and avoid side effects. New research, funded in part by the National Heart, Lung and Blood Institute (NHLBI), shows  a clear advantage of genetic testing in helping health care providers […]

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Tags: antiplatelet, antiplatelet medication, coronary heart disease, Genetic Testing, pharmacogenomics


March 7, 2021

On International Women’s Day, meet 8 trailblazing women in Mayo Clinic’s Center for Individualized Medicine

By Susan Murphy Susan Murphy (@susanmurphy)

In honor of International Women’s Day on March 8, Mayo Clinic’s Center for Individualized Medicine is celebrating the inspirational women who are taking on incredible challenges and leading the way to cure, connect and transform health care. International Women’s Day is dedicated to the social, economic, political, cultural and scientific achievements of women. This year’s […]

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Tags: #women's health, ALS, cancer, Genetic Testing, genomics, neurodegenerative disorders, rare disease, womens cancer


February 26, 2021

Mayo Clinic investigators pursue every clue to solve patients’ rare diseases

By Susan Murphy Susan Murphy (@susanmurphy)

When patients’ illnesses are a mystery and their symptoms have defied a diagnosis, they often turn to Mayo Clinic. There a team of genomic-oriented clinicians and researchers within the Center for Individualized Medicine pursue every possible clue to solve these complex cases.  As many as 30 million Americans have a rare disease. Many patients search […]

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Tags: DNA, Genetic Counseling, Genetic Sequencing, Genetic Testing, multi-omics, rare disease, Rare Disease Day


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