breast cancer
October 31, 2023
Mayo Clinic’s DNA study reveals BRCA1 mutations in 3 sisters, prompts life-changing decisions
By Susan Murphy 
Sisters often share certain genetic traits, such as hair color and facial features. But for three sisters from Minnesota, they discovered a much deeper connection — a shared genetic mutation known to dramatically increase their risk for breast and ovarian cancer. Their BRCA1 variants came to light through a Mayo Clinic Center for Individualized Medicine […]
October 18, 2023
17-gene signature linked to remission after triple-negative breast cancer treatment
By Susan Murphy
Mayo Clinic researchers have discovered a distinctive pattern in a specific set of 17 genes that may be associated with remission after treatment for triple-negative breast cancer. The multi-omics study, published in Breast Cancer Research, highlights the potential for further investigating this signature as a target for individualized medicine.
Tags: Biomedical research, center for individualized medicine, multi-omics
September 7, 2022
What is the benefit of visiting a genetic counselor?
By Susan Murphy
By Cynthia Weiss DEAR MAYO CLINIC: My grandmother and mother, as well as an aunt and a cousin, have had breast cancer. Another cousin was diagnosed with colon cancer recently. It has been suggested that I undergo genetic counseling to determine my cancer risk. As a young man, is genetic testing necessary for me? What benefit […]
Tags: center for individualized medicine, DNA Testing, gene sequencing, Genetics, genomic medicine, individualized medicine
August 1, 2022
New AI algorithm opens avenues for knowledge discoveries
In a proof-of-concept study published in Frontiers in Immunology, Hu Li, Ph.D., a Mayo Clinic Center for Individualized Medicine systems biologist, developed a new artificial intelligence (AI) algorithm which uses novel weight engineering methods to extract meaningful biological knowledge learned by AI models. He and his team applied the tool to breast cancer omic data […]
Tags: Cancer Research, center for individualized medicine, individualized medicine, mayo clinic, personalized medicine
November 22, 2021
Gather your family health history this Thanksgiving; it could save your life
By Susan Murphy
Thanksgiving Day marks Family Health History Day, an annual national public health campaign to encourage people to better understand what health characteristics run in their families. Has your mother, sister or grandmother had breast or ovarian cancer? Has your father had prostate cancer? Is there a history of colon cancer, diabetes or high cholesterol in your family? If so, you also could be at risk. John Presutti, D.O., a Mayo Clinic family medicine physician, says don’t just talk about your family health history. Act on it. It could save your life.
October 18, 2021
By Susan Murphy
When Michelle Ewy, 38, received an opportunity at Mayo Clinic to get her DNA tested for genetic mutations related to breast and ovarian cancers, and other cancers and diseases, she jumped at the chance. “I wasn’t thinking much of what the outcome would be because there has not been a prevalence of breast or ovarian […]
Tags: BRCA2, breast cancer, Dr. Konstantinos Lazaridis, Genetic Counseling, Genetic Testing, ovarian cancer, Teresa Kruisselbrink, whole exome sequencing
August 17, 2020
Mayo Clinic and Middlesex Health partner to transform genetic cancer research
By Susan Murphy
By Alyson Gonzalez What began as an inquiry sparked during a research brainstorming session, evolved into meaningful collaboration for a community cancer center in Connecticut. Through the Mayo Clinic Care Network relationship, Middlesex Health and Mayo Clinic are working together to improve the lives of cancer patients and their families through impactful research. Approximately one […]
Tags: breast cancer
August 12, 2020
Could population genetic screening improve public health?
Hereditary BRCA-related breast and ovarian cancer, Lynch syndrome and familial hypercholesterolemia are estimated to be relatively prevalent in the general population but poorly found using traditional risk screening. In a typical medical practice, genetic testing for these conditions is based on personal or family history, ethnic background or other demographic characteristics, that may not always […]
Tags: #Familial hypercholesterolemia, breast cancer, Dr. Matthew Ferber, lynch syndrome, mayo clinic, Mayo Clinic Center for Individualized Medicine, ovarian cancer, population health genomics, Research
October 21, 2019
What men need to know about breast cancer risk
Male breast cancer is a rare disease, comprising 1% of all breast cancers, but the number of men diagnosed is on the rise. “And there is an increasing appreciation of differences in the tumor biology of female breast cancer versus male breast cancer,” says Siddhartha Yadav, M.D., co-author of a Mayo Clinic study published in […]
Tags: Genetic Testing, genomics, hereditary breast cancer, hereditary cancer, Male breast cancer, Mayo Clinic Center for Individualized Medicine, Sarah Kroc, Siddhartha Yadav