Cancer
January 28, 2019
Triumph out of tragedy: A home screening test for cervical cancer
January is Cervical Health Awareness Month, a time to reflect on personalized approaches to preventing or treating cervical cancer. Harrowing stories of rampant sexual violence and high instances of cervical cancer in the Democratic Republic of Congo spurred Marina Walther-Antonio, Ph.D. to action. The emotional stories of survival and death triggered her desire to discover […]
Tags: #Cervical cancer, #Cervical cancer screening, #Democratic Republic of Congo, #HPV, #HPV screening, center for individualized medicine, Dr. Marina Walther-Antonio
January 3, 2019
Mayo Clinic discovers biological markers that could guide treatment for prostate cancer
Prostate cancer is the most common form of cancer in American men, other than skin cancer.* Statistics from the American Cancer Society show approximately 1 in 9 American men will be diagnosed with prostate cancer at some time in their lives. Mayo Clinic Center for Individualized Medicine-sponsored research released today may help families facing difficult […]
Tags: George Vasmatzis Ph.D., Gleason pattern 3 prostate cancer, John Cheville M.D., Mayo Clinic Center for Individualized Medicine, Mayo Clinic Center for Individualized Medicine Biomarker Discovery Program, Prostate Cancer
December 3, 2018
Meet Sanjay Bagaria, M.D.: new CIM associate director in Florida
By Sharon Rosen 
Hindsight is 20/20.That saying rings true for surgical oncologist Sanjay Bagaria, M.D. As a premedical student at University of Michigan, he chose to major in Japanese studies, mastering thousands of characters and a new grammar structure to read the Japanese literature he loved. Looking back, that experience gave him the tools to view not only […]
Tags: #Associate director Center for Individualized Medicine, #basal-like breast cancer, #Dr. Sanjay Bagaria, #hyperthermic intraperitoneal chemotherapy (HIPEC) surgery, #Mayo Clinic Campus in Florida, #surgical oncologist, biomarkers, center for individualized medicine, mayo clinic, medical research
November 26, 2018
Mayo Clinic discovery advances potential individualized treatment for mesothelioma
Large chromosomal rearrangements present in mesothelioma could make it possible to understand which patients are likely respond to immunotherapy, researchers at the Mayo Clinic Center for Individualized Medicine have discovered. The research is published in the Journal of Thoracic Oncology. “What we’ve shown so far is that these large complex chromosomal rearrangements are frequent in […]
Tags: #Dr. Aaron Mansfield, #mesothelioma, Cancer Research, Dr. George Vasmatzis, Mayo Clinic Center for Individualized Medicine
November 19, 2018
Gene therapy: potential and pitfalls
Research is advancing gene therapy as a possible treatment or eventual cure for genetic diseases that bedevil modern science. Gene therapy was conceived over 20 years ago, and until recently, remained largely in the research lab. But gene therapy products are now beginning to be approved by the U.S. Food and Drug Administration for clinical […]
Tags: #Brittle bone disease, #CAR T-cell therapy, #Dr. David Deyle, #gene therapy, Dr. Saad Kenderian, Mayo Clinic Center for Individualized Medicine, medical research
November 12, 2018
Novel data-driven approach for precision medicine
Thousands of patients’ tumors have been sequenced in the past decade, yielding a rich source of data on the changes associated with the cancer development and treatment response. However, there are no validated methods that are used in the clinic to select the best therapy. Today, Mayo Clinic researchers report an omics-guided (comprehensive) drug prioritization […]
Tags: #Dr. Krishna Kalari, Dr. Judy Boughey, Dr. Liewei Wang, Dr. Matthew Goetz, Mayo Clinic Center for Individualized Medicine, personal genomics, pharmacogenomics
November 5, 2018
Pharmacogenomics: finding the right drug, dose for cancer therapy
By Sharon Rosen
Each year, nearly 300,000 patients receive the lifesaving chemotherapy 5-fluorouracil (5-FU) to treat many types of cancer, including colorectal, breast, bowel, skin, pancreatic, and esophageal cancer. While it can be an effective treatment, it doesn’t work for everyone. In fact, up to 30 percent of those who receive the standard dose can have serious, life-threatening […]
Tags: #5-fluorouracil, #5-FU chemotherapy, #chemotherapy side effects, #DPYD gene, #drug-gene interactions, #gene verifier model, breast cancer, chemotherapy, colorectal cancer, mayo clinic, Mayo Clinic Cancer Center, Mayo Clinic Center for Individualized Medicine
October 29, 2018
BEAUTY trial charts an individualized path to breast cancer treatment
Article by Julie Janovsky Mason Watch Elena’s story here: Six years ago, Elena Blevins discovered a lump on her right breast as she was getting dressed. “At first I thought it was cyst,” she says, initially dismissing the lump as she focused on her job and family. After several months, she became increasingly tired. […]
Tags: #Breast Cancer Awareness Month, #Dr. Donald Northfelt, #Mayo Clinic Breast Clinic, Beauty Study, breast cancer, Mayo Clinic Arizona campus, Mayo Clinic Center for Individualized Medicine
October 15, 2018
Personalized screening: finding and treating breast cancer sooner
By Sharon Rosen
October is Breast Cancer Awareness Month, a time to reflect on new, individualized approaches to detecting and treating a cancer that affects 1 in 8 American women. Deborah Rhodes, M.D. and her Mayo Clinic colleagues are working to identify the best targeted screening tools and guidelines for women with a higher risk of developing breast […]
Tags: #breast cancer screening, #dense breast tissue, #Dr. Deborah Rhodes, #Dr. Michael O'Connor, #Dr. Myra Wick, #molecular breast imaging, 3-D mammograms, breast cancer, breast density, center for individualized medicine, Dr. Carrie Hruska, mayo clinic
September 17, 2018
CIMCON18 — how genomics discovery is transforming individualized care and the path forward
By Sharon Rosen
Mining information deeper than genomics, understanding factors linked to disease, analyzing big data, and addressing the challenges of bringing all this information together to advance patient care – these were some of the themes featured at the Individualizing Medicine Conference: Advancing Care through Genomics held in Rochester, Minnesota, Sept. 12-13, and sponsored by the Mayo […]
Tags: #All of Us Research Program biobank, #CAR T-cell therapy, #CIMCon18, #Dr. Eric Green, #Dr. Gabriel Krestin, #Dr. Manolis Kellis, #Dr. Michael Berger, #Dr. Nancy Cox, #Dr. Yi Lin, #Genomic data, All of Us Research Program, center for individualized medicine