Cancer
September 29, 2022
Addressing the challenges of chimeric antigen receptor-T cell therapy
By Susan Murphy 
Article by Marla Broadfoot Chimeric antigen receptor-T cell therapy (CAR-T cell therapy) — a type of immunotherapy that reprograms a patient’s T cells to recognize and destroy cancer cells — has revolutionized the treatment of blood cancers. While the technique has successfully sent patients with advanced disease into remission, it is far from perfect. CAR-T cell […]
Tags: #CAR T-cell therapy, center for individualized medicine, immunotherapy
September 22, 2022
Mayo Clinic researchers identify drug resistance factors for advanced prostate cancer
In a new study published in Molecular Cancer Research, Mayo Clinic researchers identified critical genomic changes in response to abiraterone acetate/prednisone, a standard treatment option for men with progressive, incurable and castration-resistant prostate cancer. “We defined a potential strategy for both responders and nonresponders of the drug that may help men overcome resistance and prolong […]
Tags: center for individualized medicine, genomic medicine, individualized medicine, mayo clinic, medical research
September 15, 2022
Designing Personalized Vaccines to Combat Cancer
By Susan Murphy
Mayo Clinic researchers are working to develop personalized therapeutic cancer vaccines that can potentially target each person’s distinctive tumor characteristics. The new approach, built on advances in genomic research and data analytics, holds transformative potential to boost the power of the immune system to identify and attack cancer cells.
Tags: Cancer Research, cancer vaccine, center for individualized medicine, Genetics, medical research, neoantigen, personalized medicine
September 7, 2022
What is the benefit of visiting a genetic counselor?
By Susan Murphy
By Cynthia Weiss DEAR MAYO CLINIC: My grandmother and mother, as well as an aunt and a cousin, have had breast cancer. Another cousin was diagnosed with colon cancer recently. It has been suggested that I undergo genetic counseling to determine my cancer risk. As a young man, is genetic testing necessary for me? What benefit […]
Tags: center for individualized medicine, DNA Testing, gene sequencing, Genetics, genomic medicine, individualized medicine
July 20, 2022
2022 Gerstner Awardee to investigate gut microbiome link to chemotherapy-induced nausea
By Susan Murphy
Dr. Singh is investigating individualized strategies to help mitigate symptoms of chemotherapy-induced nausea in patients receiving chemotherapy for breast cancer. Her research focuses on the complex link between nausea-related symptoms and the gut microbiome — a population of bacteria, viruses, and fungi that inhabit the gastrointestinal tract.
Tags: center for individualized medicine, genomic medicine, genomics
July 20, 2022
2022 Gerstner Awardee to investigate dual CAR-T cell therapy for multiple myeloma cancer
By Susan Murphy
Dr. Sakemura is working to advance immunotherapy efficacy in multiple myeloma cancer by uncovering treatment resistance mechanisms and developing a more potent immunotherapy approach. His strategy focuses on simultaneously targeting cancer cells and the ecosystem surrounding each tumor, known as the tumor microenvironment.
Tags: center for individualized medicine, Genetics, genomics, individualized medicine, medical research, Multiple Myeloma
April 25, 2022
By Susan Murphy
National DNA Day on Monday, April 25, marks the discovery of DNA’s double helix in 1953 and the Human Genome Project’s completion in 2003. For the first time, a team of scientists led by the National Institutes of Health has finished sequencing an entire human genome — all of the roughly 3 billion bases of […]
Tags: Dr. Konstantinos Lazaridis, Genetic Sequencing, Genetic Testing, Genetics, genome, Human Genome Project
April 13, 2022
Mayo Clinic researchers load CAR-T cells with oncolytic virus to treat solid cancer tumors
By Susan Murphy
Researchers at Mayo Clinic’s Center for Individualized Medicine have devised an immunotherapy technique that combines chimeric antigen receptor-T cell therapy, or CAR-T cell therapy, with a cancer-killing virus to more effectively target and treat solid cancer tumors.
Tags: #CAR T-cell therapy, center for individualized medicine, Dr. Richard Vile, genomics, individualized medicine, medical research, oncolytic virus, personalized medicine
March 31, 2022
Mayo Clinic patient grateful after genetic test leads to unexpected, early detection of colon cancer
By Susan Murphy
Alejandro Mirazo, 56, never imagined his genetic test results would reveal a hereditary link to cancer, or that his findings would potentially save his life. He had participated in a preemptive DNA research sequencing study for Mayo Clinic’s Center for Individualized Medicine in fall 2021 solely to contribute to medical research. As a Mexican American, he also wanted to add diversity to Mayo Clinic’s genomic dataset.
Tags: center for individualized medicine, DNA Testing, gene sequencing, Genetics, genomic medicine, medical research, personalized medicine
March 17, 2022
Mayo Clinic study reports genomic data disparities among racial groups
Mayo Clinic researchers studied the differences in genomic data quality among racial groups in one of the largest and most widely used cancer research datasets, The Cancer Genome Atlas. “We found lower quality genomic sequencing data in self-reported Black patients and patients of African ancestry,” says Yan Asmann., Ph.D., a Mayo Clinic bioinformatician and senior […]
Tags: Cancer Research, center for individualized medicine, DNA Testing, mayo clinic