Cancer


November 26, 2018

Mayo Clinic discovery advances potential individualized treatment for mesothelioma

By Susan Buckles susanbuckles

Large chromosomal rearrangements present in mesothelioma could make it possible to understand which patients are likely respond to immunotherapy,  researchers at the Mayo Clinic Center for Individualized Medicine  have discovered. The research is published in the Journal of Thoracic Oncology. “What we’ve shown so far is that these large complex chromosomal rearrangements are frequent in […]

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Tags: #Dr. Aaron Mansfield, #mesothelioma, Cancer Research, Dr. George Vasmatzis, Mayo Clinic Center for Individualized Medicine


November 19, 2018

Gene therapy: potential and pitfalls

By Susan Buckles susanbuckles

Research is advancing gene therapy as a possible treatment or eventual cure for genetic diseases that bedevil modern science. Gene therapy was conceived over 20 years ago, and until recently, remained largely in the research lab. But gene therapy products are now beginning to be approved by the U.S. Food and Drug Administration for clinical […]

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Tags: #Brittle bone disease, #CAR T-cell therapy, #Dr. David Deyle, #gene therapy, Dr. Saad Kenderian, Mayo Clinic Center for Individualized Medicine, medical research


Novel data-driven approach for precision medicine

November 12, 2018

Novel data-driven approach for precision medicine

By Colette Gallagher colettegallagher

Thousands of patients’ tumors have been sequenced in the past decade, yielding a rich source of data on the changes associated with the cancer development and treatment response. However, there are no validated methods that are used in the clinic to select the best therapy. Today, Mayo Clinic researchers report an omics-guided (comprehensive) drug prioritization […]

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Tags: #Dr. Krishna Kalari, Dr. Judy Boughey, Dr. Liewei Wang, Dr. Matthew Goetz, Mayo Clinic Center for Individualized Medicine, personal genomics, pharmacogenomics


November 5, 2018

Pharmacogenomics: finding the right drug, dose for cancer therapy

By Sharon Rosen sharonhrosen

Each year, nearly 300,000 patients receive the lifesaving chemotherapy 5-fluorouracil (5-FU) to treat many types of cancer, including colorectal, breast, bowel, skin, pancreatic, and esophageal cancer. While it can be an effective treatment, it doesn’t work for everyone. In fact, up to 30 percent of those who receive the standard dose can have serious, life-threatening […]

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Tags: #5-fluorouracil, #5-FU chemotherapy, #chemotherapy side effects, #DPYD gene, #drug-gene interactions, #gene verifier model, breast cancer, chemotherapy, colorectal cancer, mayo clinic, Mayo Clinic Cancer Center, Mayo Clinic Center for Individualized Medicine


October 29, 2018

BEAUTY trial charts an individualized path to breast cancer treatment

By Susan Buckles susanbuckles

Article by Julie Janovsky Mason Watch Elena’s story here:   Six years ago, Elena Blevins discovered a lump on her right breast as she was getting dressed. “At first I thought it was cyst,” she says, initially dismissing the lump as she focused on her job and family. After several months, she became increasingly tired. […]

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Tags: #Breast Cancer Awareness Month, #Dr. Donald Northfelt, #Mayo Clinic Breast Clinic, Beauty Study, breast cancer, Mayo Clinic Arizona campus, Mayo Clinic Center for Individualized Medicine


October 15, 2018

Personalized screening: finding and treating breast cancer sooner

By Sharon Rosen sharonhrosen

October is Breast Cancer Awareness Month, a time to reflect on new, individualized approaches to detecting and treating a cancer that affects 1 in 8 American women. Deborah Rhodes, M.D. and her Mayo Clinic colleagues are working to identify the best targeted screening tools and guidelines for women with a higher risk of developing breast […]

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Tags: #breast cancer screening, #dense breast tissue, #Dr. Deborah Rhodes, #Dr. Michael O'Connor, #Dr. Myra Wick, #molecular breast imaging, 3-D mammograms, breast cancer, breast density, center for individualized medicine, Dr. Carrie Hruska, mayo clinic


September 17, 2018

CIMCON18 — how genomics discovery is transforming individualized care and the path forward

By Sharon Rosen sharonhrosen

Mining information deeper than genomics, understanding factors linked to disease, analyzing big data, and addressing the challenges of bringing all this information together to advance patient care – these were some of the themes featured at the Individualizing Medicine Conference: Advancing Care through Genomics held in Rochester, Minnesota, Sept. 12-13, and sponsored by the Mayo […]

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Tags: #All of Us Research Program biobank, #CAR T-cell therapy, #CIMCon18, #Dr. Eric Green, #Dr. Gabriel Krestin, #Dr. Manolis Kellis, #Dr. Michael Berger, #Dr. Nancy Cox, #Dr. Yi Lin, #Genomic data, All of Us Research Program, center for individualized medicine


September 12, 2018

CIM CON day 1 – Precision cancer care: ‘So much power’

By Susan Buckles susanbuckles

Article by Barbara Toman Unlocking the secrets of the genetic blueprint may hold the key to both detecting and effectively treating cancer. Researchers from around the world are discussing new ways to diagnose and treat cancer at the Individualizing Medicine Conference: Advancing Care through Genomics, which started today. The Mayo Clinic Center for Individualized Medicine (CIM) […]

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Tags: #CAR T-cell therapy, #CIMCon18, #Dr. Mike Berger, #Dr. Yi Lin, #Indvidualizing Medicince Conference, cancer genomics, Genomic Sequencing, Mayo Clinic Center for Individualized Medicine, RNA sequencing


September 4, 2018

Preemptive genetic testing: could it help you take charge of your health?

By Sharon Rosen sharonhrosen

A blood pressure check, an immunization and a cholesterol test – these are all parts of your routine medical care. Someday, a genetic test to identify your risk for developing disease may also be added to the list. In fact, researchers believe that day is fast approaching thanks to the rapid advances in genomic medicine. […]

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Tags: #CIMCon18, #DNA sequencing tests, #Mayo Clinic Biobank, #pre-emptive genetic testing, center for individualized medicine, Dr. Konstantinos Lazaridis, Genetic Testing, mayo clinic, medical research, whole genome sequencing


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