Microbiome
July 21, 2021
Researchers review how sex steroids change gut, vaginal microbiome
It is well-established that the human body’s microbiome ― the bacteria in the gut ― dramatically affects health and disease. However, the role of the gut in women’s health outcomes is largely unknown. Mayo Clinic and Wellesley College researchers focused on how the interactions of steroids on gut and vaginal microbiomes influence women’s health outcomes […]
Tags: Dr. Marina Walther-Antonio, Gut Microbiome, Mayo Clinic Center for Individualized Medicine, vaginal microbiome
June 24, 2021
Mayo researchers develop algorithm to predict rheumatoid arthritis disease activity
By Susan Murphy 
Researchers within Mayo Clinic’s Center for Individualized Medicine and Division of Rheumatology have developed a first-of-its-kind machine learning algorithm that can predict rheumatoid arthritis disease activity in a patient. The algorithm analyzes biochemical metabolites ― the product of the body’s metabolism ― in blood. “Having fast, reliable and scalable measures for predicting the clinical course […]
Tags: #algorithm, genomics, Precision Medicine, Rheumatoid Arthritis
April 22, 2021
Meet 5 Mayo scientists researching ‘beyond DNA’ to advance personalized medicine
By Susan Murphy
As the nation marks National DNA Day on Sunday, April 25 — a day that commemorates the discovery of DNA’s double helix in 1953 and the completion of the Human Genome Project in 2003 — Mayo Clinic physicians and researchers will continue to closely collaborate to push the boundaries of precision medicine in the areas […]
September 15, 2020
Mayo scientists develop mathematical index to distinguish healthy microbiome from diseased
By Susan Murphy
What causes some people to develop chronic diseases such as rheumatoid arthritis, cancer and metabolic syndrome while others stay healthy? A major clue could be found in their gut microbiome — the trillions of microbes living inside the digestive system that regulate various bodily functions. To utilize the huge population of tiny organisms as a […]
Tags: bacteria, Gut Microbiome, individualized medicine, Microbiome Program
September 10, 2020
Mayo researcher finds potential microbial pathway to treat IBS symptoms, lessen abdominal pain
By Susan Murphy
Mayo Clinic researchers have found new evidence linking the millions of bacteria residing in our digestive systems, known as the microbiome, to a network of factors that drive irritable bowel syndrome (IBS). The findings, published in the Sept. 10, 2020 issue of Cell, raise the possibility of targeting the newly discovered microbial pathways to improve […]
Tags: individualized medicine, irritable bowel syndrome, microbiome, multi-omics
April 25, 2020
Why do diseases such as COVID-19 and cancer hit some people harder than others?
By Susan Murphy
As the nation marks DNA Day on April 25 — commemorating the discovery of DNA’s double helix in 1953 and the completion of the Human Genome Project in 2003 — Mayo Clinic researcher Nicholas Chia, Ph.D., continues to search for answers to the question of why some people are more susceptible to getting a severe […]
Tags: cancer genomics, DNA, genomics, microbiome, rare disease
December 11, 2019
In a first, researchers sequence single bacterial cells, paving path for rapid sepsis test
By Susan Murphy
For the first time, Mayo Clinic researchers are sequencing the genomic contents of single bacterial cells. The technique may pave the way for a potential lifesaving test for sepsis, a serious and sometimes deadly condition caused by the body’s response to an infection. Rather than waiting for days to identify the source of a patient’s […]
Tags: #sepsis, bacteria, bacterial cells, Genome Sequencing, individualized medicine
April 2, 2019
Purna Kashyap, M.B.B.S. – testing the bugs within to maintain health, detect and treat disease
By Sharon Rosen 
The use of microbiome testing – which analyzes the trillions of bacteria in and on the body – is on the move. It’s going from the research lab into the clinic to help guide patient care. DNA testing technologies have revolutionized researchers’ ability to identify individual bacterial strains driving disease. Now genomic testing is helping […]
Tags: #blood sugar levels, #Center for Individualized Medicine Microbiome Program, #diabetes, #digestive health, #glucose levels, #inflammatory bowel disease, #obesity, #personalized diet, c. difficile, center for individualized medicine, colorectal cancer, Dr. Purna Kashyap
March 5, 2019
By Sharon Rosen
Space-age technologies, DNA sequencing and artificial intelligence – all tools for discovery that Nicholas Chia, Ph.D. and his team are using to push the envelope and improve care for complex diseases like colorectal cancer. They’re collaborating with scientists from NASA to uncover how the microbiome – the trillions of microbes in and on the body […]
Tags: #ecology, #genomic testing, #Kidney stones, #microbial ecology, #systems biology, bacteria, colorectal cancer, DNA Sequencing, Dr. Nicholas Chia, gut bacteria, mayo clinic, Mayo Clinic Center for Individualized Medicine
February 8, 2019
Personalized diets: foods shaped to your lifestyle, genetics and gut
Have you ever wondered why some people can eat all they want and never gain weight while others exercise and watch what they eat but still can’t shed a pound? The clue may lie partly in your gut microbiome, the complex community of bacteria within the digestive tract that is genetically different in each person. […]
Tags: #blood glucose, #diabetes, #Dr. Vivek Iyer, #obesity, #personalized diet, #personalized nutrition, #weight loss, Dr. Helena Mendes Soares, Dr. Purna Kashyap, Mayo Clinic Center for Individualized Medicine