Microbiome

April 25, 2022

On National DNA Day, Mayo Clinic researchers put genomics into action to advance individualized medicine

By Susan Murphy Susan Murphy (@susanmurphy)

National DNA Day on Monday, April 25, marks the discovery of DNA’s double helix in 1953 and the Human Genome Project’s completion in 2003.  For the first time, a team of scientists led by the National Institutes of Health has finished sequencing an entire human genome — all of the roughly 3 billion bases of […]

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Tags: Dr. Konstantinos Lazaridis, Genetic Sequencing, Genetic Testing, Genetics, genome, Human Genome Project


December 28, 2021

10 Significant Mayo Clinic Center for Individualized Medicine studies of 2021

By Susan Murphy Susan Murphy (@susanmurphy)

It has been an impactful year of genomic and multi-omic research and scientific discoveries in Mayo Clinic’s Center for Individualized Medicine. While much focus in 2021 was centered on advancing the knowledge of COVID-19, Mayo scientists and physician have also worked to develop individualized treatments, prevention measures and diagnostics for patients with rare and undiagnosed diseases, cancer and other illnesses. 

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Tags: center for individualized medicine, DNA Testing, gene sequencing, Genetics, genomic medicine, genomics


September 14, 2021

Mayo researchers link gut microbiome to rheumatoid arthritis prognosis

By Susan Murphy Susan Murphy (@susanmurphy)

A significant indicator of whether a patient with rheumatoid arthritis will improve over the course of disease may lie in part in their gut, according to new research from Mayo Clinic’s Center for Individualized Medicine. The study, published in Genome Medicine, found that predicting a patient’s future rheumatoid arthritis prognosis could be possible by zeroing in […]

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Tags: #Dr. Jaeyun Sung, Dr. John Davis, genomics, microbiome, Rheumatoid Arthritis


August 9, 2021

Mayo Clinic analysis shows how disease, diet, and genomics interact with gut virome

By Colette Gallagher Colette Gallagher (@colettegallagher)

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Tags: center for individualized medicine, Dr. Purna Kashyap, Genetics, mayo clinic, medical research, microbiome, personalized medicine


July 21, 2021

Researchers review how sex steroids change gut, vaginal microbiome

By Colette Gallagher Colette Gallagher (@colettegallagher)

It is well-established that the human body’s microbiome ― the bacteria in the gut ― dramatically affects health and disease. However, the role of the gut in women’s health outcomes is largely unknown. Mayo Clinic and Wellesley College researchers focused on how the interactions of steroids on gut and vaginal microbiomes influence women’s health outcomes […]

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Tags: Dr. Marina Walther-Antonio, Gut Microbiome, Mayo Clinic Center for Individualized Medicine, vaginal microbiome


June 24, 2021

Mayo researchers develop algorithm to predict rheumatoid arthritis disease activity

By Susan Murphy Susan Murphy (@susanmurphy)

Researchers within Mayo Clinic’s Center for Individualized Medicine and Division of Rheumatology have developed a first-of-its-kind machine learning algorithm that can predict rheumatoid arthritis disease activity in a patient. The algorithm analyzes biochemical metabolites ― the product of the body’s metabolism ― in blood. “Having fast, reliable and scalable measures for predicting the clinical course […]

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Tags: #algorithm, genomics, Precision Medicine, Rheumatoid Arthritis


April 22, 2021

Meet 5 Mayo scientists researching ‘beyond DNA’ to advance personalized medicine

By Susan Murphy Susan Murphy (@susanmurphy)

As the nation marks National DNA Day on Sunday, April 25 — a day that commemorates the discovery of DNA’s double helix in 1953 and the completion of the Human Genome Project in 2003 — Mayo Clinic physicians and researchers will continue to closely collaborate to push the boundaries of precision medicine in the areas […]

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September 15, 2020

Mayo scientists develop mathematical index to distinguish healthy microbiome from diseased

By Susan Murphy Susan Murphy (@susanmurphy)

What causes some people to develop chronic diseases such as rheumatoid arthritis, cancer and metabolic syndrome while others stay healthy? A major clue could be found in their gut microbiome — the trillions of microbes living inside the digestive system that regulate various bodily functions. To utilize the huge population of tiny organisms as a […]

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Tags: bacteria, Gut Microbiome, individualized medicine, Microbiome Program


September 10, 2020

Mayo researcher finds potential microbial pathway to treat IBS symptoms, lessen abdominal pain

By Susan Murphy Susan Murphy (@susanmurphy)

Mayo Clinic researchers have found new evidence linking the millions of bacteria residing in our digestive systems, known as the microbiome, to a network of factors that drive irritable bowel syndrome (IBS). The findings, published in the Sept. 10, 2020 issue of Cell, raise the possibility of targeting the newly discovered microbial pathways to improve […]

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Tags: individualized medicine, irritable bowel syndrome, microbiome, multi-omics


April 25, 2020

Why do diseases such as COVID-19 and cancer hit some people harder than others?

By Susan Murphy Susan Murphy (@susanmurphy)

As the nation marks DNA Day on April 25 — commemorating the discovery of DNA’s double helix in 1953 and the completion of the Human Genome Project in 2003 — Mayo Clinic researcher Nicholas Chia, Ph.D., continues to search for answers to the question of why some people are more susceptible to getting a severe […]

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Tags: cancer genomics, DNA, genomics, microbiome, rare disease


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