Research

October 18, 2021

Large-scale exome sequencing project spots disease-fueling mutations to save lives, accelerate discoveries

By Susan Murphy Susan Murphy (@susanmurphy)

When Michelle Ewy, 38, received an opportunity at Mayo Clinic to get her DNA tested for genetic mutations related to breast and ovarian cancers, and other cancers and diseases, she jumped at the chance.  “I wasn’t thinking much of what the outcome would be because there has not been a prevalence of breast or ovarian […]

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Tags: BRCA2, breast cancer, Dr. Konstantinos Lazaridis, Genetic Counseling, Genetic Testing, ovarian cancer, Teresa Kruisselbrink, whole exome sequencing


October 13, 2021

Mayo Clinic collaborates with Personalis Inc. to expand cancer genomic testing

By Susan Murphy Susan Murphy (@susanmurphy)

By Joe Dangor Mayo Clinic announced an agreement on Tuesday, Oct. 12 that will allow it to offer clinical-grade comprehensive cancer genomic sequencing to cancer patients who choose to participate. Test results will be available to patients and their treating health care providers to guide therapeutic decisions, advance cancer research, and support the development of […]

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Tags: cancer genomics, Dr. Konstantinos Lazaridis, Genetic Testing, Mayo Clinic Cancer Center


September 20, 2021

Mayo Clinic leads biorepository core for new nationwide research on long-term symptoms of COVID-19

By Colette Gallagher Colette Gallagher (@colettegallagher)

Mayo Clinic research is dedicated to finding solutions for patients who were infected with COVID-19 and the many affected by the long-term symptoms of COVID-19 ― what the National Institutes of Health (NIH) refers to as “long COVID” or post-acute sequelae. In response to great unmet patient need, the NIH launched a new research initiative […]

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Tags: center for individualized medicine, covid-19, Dr. Mine Cicek, Dr. R.Ross Reichard, Dr. Ryan Hurt, Dr. Stephen Thibodeau, Dr. Thomas Flotte, individualized medicine, long-COVID, mayo clinic, mayo clinic laboratories, medical research


August 30, 2021

2021 Gerstner Awardees to investigate individualized medicine approaches for heart attack and leukemia

By Susan Murphy Susan Murphy (@susanmurphy)

Moritz Binder M.D., a physician-scientist in Mayo Clinic’s divisions of Hematology and Oncology, and Satsuki Yamada, M.D., Ph.D., a physician-scientist in the division of Cardiovascular Diseases, are recipients of the 2021 Gerstner Family Career Development Awards.  The competitive awards are presented annually by Mayo Clinic Center for Individualized Medicine to researchers conducting innovative investigations to […]

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July 21, 2021

Researchers review how sex steroids change gut, vaginal microbiome

By Colette Gallagher Colette Gallagher (@colettegallagher)

It is well-established that the human body’s microbiome ― the bacteria in the gut ― dramatically affects health and disease. However, the role of the gut in women’s health outcomes is largely unknown. Mayo Clinic and Wellesley College researchers focused on how the interactions of steroids on gut and vaginal microbiomes influence women’s health outcomes […]

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Tags: Dr. Marina Walther-Antonio, Gut Microbiome, Mayo Clinic Center for Individualized Medicine, vaginal microbiome


July 1, 2021

Newly discovered genetic variants in a single gene cause neurodevelopmental disorder, Mayo study finds

By Susan Murphy Susan Murphy (@susanmurphy)

Rochester, Minn. — Mayo Clinic researchers have discovered that genetic variants in a neuro-associated gene called SPTBN1 are responsible for causing a neurodevelopmental disorder. The study, published in Nature Genetics, is a first step in finding a potential therapeutic strategy for this disorder, and it increases the number of genes known to be associated with […]

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Tags: #neurological diseases, Dr. Margot Cousin, genomics


June 15, 2021

New Mayo study validates melanoma test to help some patients avoid surgical biopsy

By Susan Murphy Susan Murphy (@susanmurphy)

More than 100,00 people in the U.S. are expected to be diagnosed with melanoma this year — double the number of cases compared to 30 years ago, according to the American Academy of Dermatology Association.  “Melanoma accounts for only about 2% of skin cancers, but it causes a majority of skin cancer deaths,” says Alexander […]

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Tags: #Dr. Alexander Meves, Melanoma


June 8, 2021

Mayo researchers study genetic basis of high cholesterol in adults

By Colette Gallagher Colette Gallagher (@colettegallagher)

In a new study published in NPJ Genomic Medicine, Mayo Clinic researchers found that genetic testing may help identify patients with high cholesterol, or hypercholesterolemia. It also may have implications for the clinical management of patients diagnosed with high cholesterol due to a genetic disorder, or familial hypercholesterolemia. “In our study, we found more than […]

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Tags: #Familial hypercholesterolemia, #High cholesterol, Dr. Iftikhar Kullo, Heart Disease, mayo clinic, Mayo Clinic Center for Individualized Medicine


June 4, 2021

Groundbreaking Early Cancer Detection Test Studied at Mayo Clinic Introduced Nationally

By Colette Gallagher Colette Gallagher (@colettegallagher)

Mayo Clinic today recognized the debut of a groundbreaking multi-cancer early cancer detection (MCED) test called Galleri™ that can detect more than 50 types of cancers[1] through a simple blood draw. The Galleri test is intended  to complement U.S. guideline-recommended cancer screenings. Mayo Clinic Oncologist Minetta Liu, M.D. was involved in the development of the […]

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Tags: #Dr. Minetta Liu, Cancer Research, mayo clinic, Mayo Clinic Center for Individualized Medicine


May 25, 2021

Gene fusion discovery in ultrarare tumor highlights potential therapeutic target

By Susan Murphy Susan Murphy (@susanmurphy)

A scientific investigation led by a team of researchers from Mayo Clinic’s Center for Individualized Medicine reveals that an ultrarare cancer called epithelioid trophoblastic tumor (ETT), which can develop in the uterus after conception, recurrently exhibits an abnormal fusion of two genes. This fusion creates an unusual protein that triggers aggressive cell growth — the […]

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Tags: #Gavin Oliver, Dr. Eric Klee


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