Research
May 9, 2022
By Susan Murphy 
Mark Pearce, 61, was facing a possible limb amputation, even death, when a multidrug-resistant bacterial infection within his prosthetic hip replacement device started raging in his bloodstream. With his fever soaring to more than 105 degrees, Mark was taken by ambulance, that day in spring of 2020, to Mayo Clinic Hospital in Rochester, Minnesota.
Tags: #bacterial infections, bacteria, bacteriophage therapy, center for individualized medicine, Dr. Gina Suh, Dr. Mark Pagnano, genomics, individualized medicine, infectious disease, personalized medicine, phage therapy
May 5, 2022
Mayo research using DNA to catch cancer, other medical conditions earlier
What would happen if a certain percentage of serious medical conditions, including cancer diagnoses, were found significantly earlier by studying the entire genome of patients’ DNA? How would their quality of life improve, and how many fewer cancer deaths would there be each year? That’s what a group of Mayo Clinic scientists and clinicians aim […]
Tags: center for individualized medicine, DNA Testing, genomics, individualized medicine, mayo clinic, medical research
April 25, 2022
By Susan Murphy
National DNA Day on Monday, April 25, marks the discovery of DNA’s double helix in 1953 and the Human Genome Project’s completion in 2003. For the first time, a team of scientists led by the National Institutes of Health has finished sequencing an entire human genome — all of the roughly 3 billion bases of […]
Tags: Dr. Konstantinos Lazaridis, Genetic Sequencing, Genetic Testing, Genetics, genome, Human Genome Project
April 13, 2022
Mayo Clinic researchers load CAR-T cells with oncolytic virus to treat solid cancer tumors
By Susan Murphy
Researchers at Mayo Clinic’s Center for Individualized Medicine have devised an immunotherapy technique that combines chimeric antigen receptor-T cell therapy, or CAR-T cell therapy, with a cancer-killing virus to more effectively target and treat solid cancer tumors.
Tags: #CAR T-cell therapy, center for individualized medicine, Dr. Richard Vile, genomics, individualized medicine, medical research, oncolytic virus, personalized medicine
March 31, 2022
Mayo Clinic patient grateful after genetic test leads to unexpected, early detection of colon cancer
By Susan Murphy
Alejandro Mirazo, 56, never imagined his genetic test results would reveal a hereditary link to cancer, or that his findings would potentially save his life. He had participated in a preemptive DNA research sequencing study for Mayo Clinic’s Center for Individualized Medicine in fall 2021 solely to contribute to medical research. As a Mexican American, he also wanted to add diversity to Mayo Clinic’s genomic dataset.
Tags: center for individualized medicine, DNA Testing, gene sequencing, Genetics, genomic medicine, medical research, personalized medicine
March 21, 2022
Mayo Clinic discovery in bone marrow cancer points to potential drug targets
By Susan Murphy
New research from Mayo Clinic’s Center for Individualized Medicine finds that patients with ASXL1-mutant chronic myelomonocytic leukemia — an uncommon type of cancer of the bone marrow — have distinctive epigenetic changes that can activate harmful genes and cause the cancer to grow faster. The ASXL1 genetic mutation also can transform the disease into the more aggressive acute myeloid leukemia. […]
Tags: #acute myeloid leukemia, #chronic myelomonocytic leukemia, center for individualized medicine, genomic medicine, genomics, medical research
March 17, 2022
Mayo Clinic study reports genomic data disparities among racial groups
Mayo Clinic researchers studied the differences in genomic data quality among racial groups in one of the largest and most widely used cancer research datasets, The Cancer Genome Atlas. “We found lower quality genomic sequencing data in self-reported Black patients and patients of African ancestry,” says Yan Asmann., Ph.D., a Mayo Clinic bioinformatician and senior […]
Tags: Cancer Research, center for individualized medicine, DNA Testing, mayo clinic
March 11, 2022
By Susan Murphy
A growing number of people are dying from antibiotic-resistant infections. These infections are fueled by microbial species that are mutating to evade the drugs developed to destroy them. More than 1.2 million people worldwide died in 2019 from antibiotic-resistant infections. In response, a team of researchers from Mayo Clinic’s Center for Individualized Medicine has developed […]
Tags: antibiotic-resistant, bacteria, center for individualized medicine, Genetics, genomics, infectious disease, personalized medicine
February 28, 2022
Young girl with rare disease gets life-changing diagnosis and targeted therapy at Mayo Clinic
By Susan Murphy
Araeya Sell, 13, has spent much of her childhood visiting her health care team and in the hospital. She has endured countless blood draws, scans, procedures and a surgery ― all in the search for answers to her complex symptoms. After an exhaustive, nearly seven-year diagnostic odyssey, the Sells turned to Mayo Clinic.
Tags: center for individualized medicine, Dr. Konstantinos Lazaridis, Dr. Pinto e Vairo, Genetics, genomics
February 16, 2022
Mass spectrometry-based assay detects viral antigens directly from clinical specimens
By Susan Murphy
By Mayo Clinic Laboratories In a newly published study, a team from Mayo Clinic’s Advanced Diagnostics Laboratory has developed a mass spectrometry-based assay that’s able to detect COVID-19 (SARS-CoV-2) pathogens from human proteins with, remarkably, 98% sensitivity and 100% specificity. This is the first assay of its kind that can detect viral antigens “directly from clinical specimens” such […]
Tags: center for individualized medicine, covid-19, Dr. Akhilesh Pandey, Mayo Clinic Advanced Diagnostic Laboratory