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August 22, 2022
Mayo Clinic study reveals aging speeds genomic mutations in brain
Somatic mutations naturally occur in cells throughout human development and during aging. However, it has yet to be determined whether the frequency of somatic mutations in the population are a contributing factor to the cause of neuropsychiatric disorders, cancers, and various diseases. Alexej Abyzov, Ph.D., a Mayo Clinic genomics researcher, seeks to gain a better […]
February 24, 2022
Curiosity paves path to precision medicine research
By Susan Murphy 
By Mayo Clinic Alumni Magazine When John Giudicessi, M.D., Ph.D., was growing up in Des Moines, Iowa, he fueled his incessant curiosity by taking apart unused items in the family’s basement. He caught frogs and turtles in a backyard creek. He loved figuring out how things worked. His parents encouraged him to ask questions. Dr. Giudicessi […]
Tags: center for individualized medicine, DNA Testing, Genetics, genomic medicine, genomics, individualized medicine, medical research
January 6, 2022
Mayo researchers lay foundation for AI-based personalized cancer modeling
By Sara Tiner
Like the maps that drivers use to get from one place to another, the goal of a medical diagnosis is to get you from where you are to where you want to be. A diagnosis takes a patient from symptoms to treatment, such as from lump to cure in the case of breast cancer. Medical […]
Tags: #Artificial Intelligence, cancer, Cancer Research, center for individualized medicine, genomic medicine, individualized medicine
October 1, 2021
Mayo Clinic’s president and CEO to reflect on evolution of individualized medicine
By Susan Murphy
In a keynote address at the virtual 10th Annual Individualizing Medicine Conference Oct. 8–9, Gianrico Farrugia, M.D., president and CEO of Mayo Clinic, will discuss the evolution and history of individualized medicine. He will highlight some of the top genomics and multi-omics initiatives that are accelerating discoveries and helping to precisely diagnose, treat and predict […]
August 18, 2021
Uterine microbe found to have disease-causing behavior in endometrial cancer
By Susan Murphy
A tiny microbe thriving in the uterine microbiome — a population of bacteria, viruses, yeasts/fungi in and around the uterus— could be a contributing driver of endometrial cancer, according to a new Mayo Clinic study. “We have found that a microbe that is particularly associated with endometrial cancer is capable of pathogenic behavior, and is […]
Tags: Endometrial cancer, genomics, individualized medicine, Omics
July 29, 2021
Transforming clinical practice and changing outcomes for brain tumor patients
For patients with glioma, life after brain tumor diagnosis can be daunting. Treatment might be intense and invasive or, conversely, impossible due to the tumor’s location, grade or lack of therapeutic response. The genetic variability of glioma and its more advanced relative glioblastoma has made genetic testing to effectively identify biomarkers associated with prognosis and […]
July 15, 2021
Genetic variants influence migraine treatment response, according to new Mayo study
By Susan Murphy
Migraines affect nearly 40 million people in the U.S. Yet pinpointing an effective prophylactic medication ― the most commonly prescribed drugs for people diagnosed with migraines ― remains a long and complex process. Patients often cycle through medications for weeks or months until achieving a therapeutic response. Now after years of slow progress in migraine […]
April 19, 2021
Mayo study finds colon cancer driven by hereditary gene mutations in 1 in 6 patients
By Susan Murphy
A new Mayo Clinic study bolsters evidence that colorectal cancer is often imprinted in family genes and passed on from one generation to the next. In the study, published in Clinical Gastroenterology and Hepatology, researchers within the Mayo Clinic Center for Individualized Medicine found 1 in 6 patients with colorectal cancer had an inherited cancer-related […]
March 18, 2021
New Framework Leads to Surprise in Early Human Development
By Sara Tiner
Mayo Clinic and Yale University scientists have developed a minimally invasive process for studying early cell development in a living person. The team reconstructed the cell history of two adult volunteers from just after cell fertilization. They found that in the first cell divide — 29 years earlier for one volunteer and 66 years earlier […]
Tags: cells, genome, individualized medicine, Research
March 17, 2021
Data show clear benefit from genetic testing before prescribing antiplatelet therapy
By Susan Murphy
By Terri Malloy Pharmacogenomics is a valuable tool for health care providers to help prescribe the right drug for the right patient to enhance efficacy and avoid side effects. New research, funded in part by the National Heart, Lung and Blood Institute (NHLBI), shows a clear advantage of genetic testing in helping health care providers […]
Tags: antiplatelet, antiplatelet medication, coronary heart disease, Genetic Testing, pharmacogenomics