Items Tagged ‘Biomedical research’

October 18, 2023

17-gene signature linked to remission after triple-negative breast cancer treatment 

By Susan Murphy Susan Murphy (@susanmurphy)

Mayo Clinic researchers have discovered a distinctive pattern in a specific set of 17 genes that may be associated with remission after treatment for triple-negative breast cancer. The multi-omics study, published in Breast Cancer Research, highlights the potential for further investigating this signature as a target for individualized medicine. 

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Tags: Biomedical research, center for individualized medicine, multi-omics


September 12, 2023

New Mayo Clinic individualized medicine leader on a quest to bring cutting-edge medicine to all

By Susan Murphy Susan Murphy (@susanmurphy)

 As a pulmonologist and genomic scientist, Victor Ortega, M.D., Ph.D., is leading a charge to breathe new life into precision medicine advancements. His mission is rooted in a deep commitment to health equities and inspired by his grandmother.  “My grandmother died of asthma, and that should not have happened. She was Puerto Rican like me, […]

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Tags: Biomedical research, center for individualized medicine, Dr. Victor Ortega, genomic medicine


August 31, 2023

Mayo Clinic cancer researchers targeting racial disparities in genomic data

By Susan Murphy Susan Murphy (@susanmurphy)

Standing at the forefront of Mayo Clinic’s genomics advancements, Yan Asmann, Ph.D., and Aaron Mansfield, M.D. are working to tailor the diagnosis and treatment of certain cancers to a person’s unique genomic makeup.  As a bioinformatician, Dr. Asmann is pursuing individualized therapeutic cancer vaccines that target a person’s distinctive tumor characteristics.   Dr. Mansfield, a […]

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Tags: Biomedical research, center for individualized medicine


August 24, 2023

Confronting polycystic kidney disease, a silent killer

By Susan Murphy Susan Murphy (@susanmurphy)

By Marla Broadfoot, Ph.D. When Fouad Chebib, M.D., was 16 years old, his father sat him and his sister down and told them he had polycystic kidney disease (PKD). The kidneys of people with the condition become jammed with dense, fluid-filled sacs, causing them to increase in size and decrease in function. His father’s kidneys were already failing, […]

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Tags: Biomedical research, polycystic kidney disease


August 16, 2023

Mayo Clinic researchers use new innovative technology to diagnose teen brothers with ultra-rare genetic disorder

By Susan Murphy Susan Murphy (@susanmurphy)

When Emery Diffendorfer was a baby, he couldn’t hold his head up or babble like other infants his age. His rare genetic disorder enlarged his tongue and head, and he had weakened muscle tone, brittle bones, sleep apnea, poor eyesight and persistent infections in his tonsils and adenoids.  By six months old, the tiny Mayo […]

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Tags: Biomedical research


August 10, 2023

Mayo Clinic ‘mini-brain’ study reveals possible key link to autism spectrum disorder

By Susan Murphy Susan Murphy (@susanmurphy)

Using human “mini-brain” models known as organoids, Mayo Clinic and Yale University scientists have discovered that the roots of autism spectrum disorder may be associated with an imbalance of specific neurons that play a critical role in how the brain communicates and functions. The specific cells are known as excitatory cortical neurons. The new study […]

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Tags: Alexej Abyzov, autism, Biomedical research, center for individualized medicine, genomic medicine, organoids


August 1, 2023

2023 Gerstner Awardee’s ‘evolutionary therapy’ targets pancreatic cancer treatment resistance

By Susan Murphy Susan Murphy (@susanmurphy)

Ryan Carr, M.D., Ph.D., a medical oncologist in Mayo Clinic’s Department of Oncology, is a recipient of the 2023 Gerstner Family Career Development Award. The competitive awards are presented annually by Mayo Clinic Center for Individualized Medicine to researchers conducting innovative investigations to predict, prevent, treat and cure diseases using individualized medicine approaches. Dr. Carr […]

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Tags: Biomedical research, center for individualized medicine, Pancreatic Cancer


August 1, 2023

2023 Gerstner Awardee to investigate individualized treatment strategy for follicular lymphoma

By Susan Murphy Susan Murphy (@susanmurphy)

Patrizia Mondello, M.D., Ph.D., M.Sc., a physician-scientist in Mayo Clinic’s Department of Hematology, is a recipient of the annual 2023 Gerstner Family Career Development Award from the Mayo Clinic Center for Individualized Medicine. The competitive awards advance innovative research to predict, prevent, treat, and cure diseases using individualized medicine.  Inspired by a 20-year-old woman named […]

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Tags: Biomedical research, center for individualized medicine, genomic medicine


July 21, 2023

Mayo Clinic researchers pave the way for individualized obesity therapy, tailoring interventions to a person’s needs

By Colette Gallagher Colette Gallagher (@colettegallagher)

In a pilot study of 165 people, Mayo Clinic researchers looked at the effectiveness of two different approaches to weight loss: a standard lifestyle intervention and individualized therapy. The standard lifestyle intervention included a reduced diet, exercise and behavior therapy. The individualized approach was based on phenotypes and included different interventions depending on the person’s […]

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Tags: Biomedical research, center for individualized medicine, Dr. Andres Acosta, genomic medicine, mayo clinic


July 19, 2023

Mayo Clinic scientists cracking the genetic code of disease-causing bacterial species to improve patient outcomes

By Susan Murphy Susan Murphy (@susanmurphy)

Mayo Clinic scientists are building an expansive library of DNA blueprints of disease-causing bacterial species. The unique collection of genomic sequences is serving as a reference database to help doctors provide rapid and precise diagnoses and pinpoint targeted treatments to potentially improve patient outcomes.

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Tags: #bacterial infections, Biomedical research, center for individualized medicine, DNA Testing, genomics


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