Items Tagged ‘breast cancer’

November 5, 2018

Pharmacogenomics: finding the right drug, dose for cancer therapy

By Sharon Rosen sharonhrosen

Each year, nearly 300,000 patients receive the lifesaving chemotherapy 5-fluorouracil (5-FU) to treat many types of cancer, including colorectal, breast, bowel, skin, pancreatic, and esophageal cancer. While it can be an effective treatment, it doesn’t work for everyone. In fact, up to 30 percent of those who receive the standard dose can have serious, life-threatening […]

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Tags: #5-fluorouracil, #5-FU chemotherapy, #chemotherapy side effects, #DPYD gene, #drug-gene interactions, #gene verifier model, breast cancer, chemotherapy, colorectal cancer, mayo clinic, Mayo Clinic Cancer Center, Mayo Clinic Center for Individualized Medicine


October 29, 2018

BEAUTY trial charts an individualized path to breast cancer treatment

By Susan Buckles susanbuckles

Article by Julie Janovsky Mason Watch Elena’s story here:   Six years ago, Elena Blevins discovered a lump on her right breast as she was getting dressed. “At first I thought it was cyst,” she says, initially dismissing the lump as she focused on her job and family. After several months, she became increasingly tired. […]

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Tags: #Breast Cancer Awareness Month, #Dr. Donald Northfelt, #Mayo Clinic Breast Clinic, Beauty Study, breast cancer, Mayo Clinic Arizona campus, Mayo Clinic Center for Individualized Medicine


October 15, 2018

Personalized screening: finding and treating breast cancer sooner

By Sharon Rosen sharonhrosen

October is Breast Cancer Awareness Month, a time to reflect on new, individualized approaches to detecting and treating a cancer that affects 1 in 8 American women. Deborah Rhodes, M.D. and her Mayo Clinic colleagues are working to identify the best targeted screening tools and guidelines for women with a higher risk of developing breast […]

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Tags: #breast cancer screening, #dense breast tissue, #Dr. Deborah Rhodes, #Dr. Michael O'Connor, #Dr. Myra Wick, #molecular breast imaging, 3-D mammograms, breast cancer, breast density, center for individualized medicine, Dr. Carrie Hruska, mayo clinic


August 27, 2018

Gerstner awards boost research into hereditary cancer, Parkinson’s disease

By Susan Buckles susanbuckles

Creating tools to detect cancer at an early stage and advancing research into the genetic links to Parkinson’s disease are focuses of the 2018 Gerstner Family Career Development Awards. This year’s winners are Niloy ‘Jewel’ Samadder, M.D., a gastroenterologist at Mayo’s Arizona campus whose research focuses on inherited cancer, and Fabienne Fiesel, Ph.D., a neurosciences […]

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Tags: #Parkinson's disease, breast cancer, colon cancer, Dr. Niloy "Jewel" Samadder, Gertsner Family Career Development Awards, hereditary cancer, Mayo Clinic Center for Individualized Medicine, ovarian cancer, Pancreatic Cancer


February 13, 2018

New international practice guidelines for using tamoxifen to treat breast cancer

By Colette Gallagher colettegallagher

An international group of clinicians and scientists representing the Clinical Pharmacogenetics Implementation Consortium (CPIC) published the first-ever clinical practice guideline for using CYP2D6 genotype to guide tamoxifen therapy in Clinical Pharmacology and Therapeutics. Tamoxifen is a hormonal agent used for the prevention and treatment of premenopausal and postmenopausal breast cancer that is estrogen receptor positive. […]

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Tags: #CIMCon18, #clinical guidelines, #Clinical Pharmacogenetics Implementation Consortium, #CYP2D6 geneotype, #estrogen receptor positive breast cancer, #tamoxifen, #targeted therapies, breast cancer, center for individualized medicine, DNA Sequencing, Dr. Matthew Goetz, Genetic Testing


November 30, 2017

3 ways Mayo Clinic is advancing individualized approaches to breast cancer treatment

By Sharon Rosen sharonhrosen

By Sharon Rosen and Susan Buckles Approximately one out of eight American women will develop breast cancer during their lifetime. In the U.S., it is estimated that more than 315,000 women will be diagnosed this year with breast cancer. While statistics show fewer women are dying from the disease, breast cancer still remains the second […]

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Tags: #blood tests, #breast cancer screening, #cancer detection, #cancer treatment, #Dr. Ciara O'Sullivan, #Dr. Minetta Liu, #genetic factors, #individualized therapy, #liquid biopsies, #xenografts, Beauty Study, breast cancer


October 3, 2017

Liquid biopsies: detecting and treating cancer sooner

By Sharon Rosen sharonhrosen

What if a blood test could discover cancer before a tumor first appears or before the first signs of cancer recurrence are seen by a radiology study? In fact, these types of blood tests, often called liquid biopsies, are already changing clinical care for patients with cancer. Researchers and physicians in Mayo Clinic Center for […]

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Tags: #blood tests, #cancer treatment, #cell-free DNA testing, #CIMCon17, #circulating tumor cells, #Dr. Minetta Liu, #Individualizing Medicine 2017, #liquid biopsies, Advanced Cancer, breast cancer, cancer, cancer screening


May 23, 2017

Picture perfect: 3-D mammograms and molecular breast imaging – personalized approaches to breast cancer screening

By Sharon Rosen sharonhrosen

A picture is worth a thousand words. While that saying may be true, for the more than 50 percent of all women who have dense breast tissue, a picture from traditional, 2-D mammography may not tell the full story about whether they have breast cancer. “Breast density is like the wolf in sheep’s clothing. Both […]

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Tags: #breast cancer screening, #dense breast tissue, #Dr. Deborah Rhodes, #MBI, #molecular breast imaging, #personalized therapies, #tomosynthesis, 2-D mammograms, 3-D mammograms, breast cancer, breast density, center for individualized medicine


May 19, 2017

Personalized care for aggressive breast cancers: 4 steps forward from the BEAUTY study

By Sharon Rosen sharonhrosen

Chemotherapy substantially reduces the chance that certain types of breast cancer will return or spread to other parts of the body and improves survival. Chemotherapy before surgery is a standard approach to treat women with aggressive breast cancer. However, chemotherapy does not shrink tumors in all women. Mayo Clinic researchers are turning to genomic sequencing […]

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Tags: #aggressive breast cancer, #chemotherapy-resistant cancer, #patient derived xenografts, #PDX, #personalized therapies, #xenografts, Beauty Study, biomarkers, breast cancer, center for individualized medicine, chemotherapy, DNA Sequencing


May 17, 2017

A chain reaction: benefactor support for early career investigators leads to new discovery to fight breast cancer

By Sharon Rosen sharonhrosen

New perspectives lead to new, groundbreaking discoveries. That’s why Mayo Clinic and the Center for Individualized Medicine support young investigators and the fresh thinking they bring to research. The Gerstner Family Foundation supports young investigators Thanks to the Gerstner Family Foundation’s support, Betty Y.S. Kim, M.D., Ph.D., a neurosurgeon and neuroscientist at Mayo Clinic’s Florida […]

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Tags: #CIMCon17, #Dr. Betty Kim, #Gerstner Family Career Development Award, #nanoparticles, #Nature Nanotechnology, breast cancer, cancer, center for individualized medicine, Gerstner Family Foundation, mayo clinic, medical research


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