Items Tagged ‘breast cancer’
November 5, 2018
Pharmacogenomics: finding the right drug, dose for cancer therapy
By Sharon Rosen 
Each year, nearly 300,000 patients receive the lifesaving chemotherapy 5-fluorouracil (5-FU) to treat many types of cancer, including colorectal, breast, bowel, skin, pancreatic, and esophageal cancer. While it can be an effective treatment, it doesn’t work for everyone. In fact, up to 30 percent of those who receive the standard dose can have serious, life-threatening […]
Tags: #5-fluorouracil, #5-FU chemotherapy, #chemotherapy side effects, #DPYD gene, #drug-gene interactions, #gene verifier model, breast cancer, chemotherapy, colorectal cancer, mayo clinic, Mayo Clinic Cancer Center, Mayo Clinic Center for Individualized Medicine
October 29, 2018
BEAUTY trial charts an individualized path to breast cancer treatment
Article by Julie Janovsky Mason Watch Elena’s story here: Six years ago, Elena Blevins discovered a lump on her right breast as she was getting dressed. “At first I thought it was cyst,” she says, initially dismissing the lump as she focused on her job and family. After several months, she became increasingly tired. […]
Tags: #Breast Cancer Awareness Month, #Dr. Donald Northfelt, #Mayo Clinic Breast Clinic, Beauty Study, breast cancer, Mayo Clinic Arizona campus, Mayo Clinic Center for Individualized Medicine
October 15, 2018
Personalized screening: finding and treating breast cancer sooner
By Sharon Rosen
October is Breast Cancer Awareness Month, a time to reflect on new, individualized approaches to detecting and treating a cancer that affects 1 in 8 American women. Deborah Rhodes, M.D. and her Mayo Clinic colleagues are working to identify the best targeted screening tools and guidelines for women with a higher risk of developing breast […]
Tags: #breast cancer screening, #dense breast tissue, #Dr. Deborah Rhodes, #Dr. Michael O'Connor, #Dr. Myra Wick, #molecular breast imaging, 3-D mammograms, breast cancer, breast density, center for individualized medicine, Dr. Carrie Hruska, mayo clinic
August 27, 2018
Gerstner awards boost research into hereditary cancer, Parkinson’s disease
Creating tools to detect cancer at an early stage and advancing research into the genetic links to Parkinson’s disease are focuses of the 2018 Gerstner Family Career Development Awards. This year’s winners are Niloy ‘Jewel’ Samadder, M.D., a gastroenterologist at Mayo’s Arizona campus whose research focuses on inherited cancer, and Fabienne Fiesel, Ph.D., a neurosciences […]
Tags: #Parkinson's disease, breast cancer, colon cancer, Dr. Niloy "Jewel" Samadder, Gertsner Family Career Development Awards, hereditary cancer, Mayo Clinic Center for Individualized Medicine, ovarian cancer, Pancreatic Cancer
February 13, 2018
New international practice guidelines for using tamoxifen to treat breast cancer
An international group of clinicians and scientists representing the Clinical Pharmacogenetics Implementation Consortium (CPIC) published the first-ever clinical practice guideline for using CYP2D6 genotype to guide tamoxifen therapy in Clinical Pharmacology and Therapeutics. Tamoxifen is a hormonal agent used for the prevention and treatment of premenopausal and postmenopausal breast cancer that is estrogen receptor positive. […]
Tags: #CIMCon18, #clinical guidelines, #Clinical Pharmacogenetics Implementation Consortium, #CYP2D6 geneotype, #estrogen receptor positive breast cancer, #tamoxifen, #targeted therapies, breast cancer, center for individualized medicine, DNA Sequencing, Dr. Matthew Goetz, Genetic Testing
November 30, 2017
3 ways Mayo Clinic is advancing individualized approaches to breast cancer treatment
By Sharon Rosen
By Sharon Rosen and Susan Buckles Approximately one out of eight American women will develop breast cancer during their lifetime. In the U.S., it is estimated that more than 315,000 women will be diagnosed this year with breast cancer. While statistics show fewer women are dying from the disease, breast cancer still remains the second […]
Tags: #blood tests, #breast cancer screening, #cancer detection, #cancer treatment, #Dr. Ciara O'Sullivan, #Dr. Minetta Liu, #genetic factors, #individualized therapy, #liquid biopsies, #xenografts, Beauty Study, breast cancer
October 3, 2017
Liquid biopsies: detecting and treating cancer sooner
By Sharon Rosen
What if a blood test could discover cancer before a tumor first appears or before the first signs of cancer recurrence are seen by a radiology study? In fact, these types of blood tests, often called liquid biopsies, are already changing clinical care for patients with cancer. Researchers and physicians in Mayo Clinic Center for […]
Tags: #blood tests, #cancer treatment, #cell-free DNA testing, #CIMCon17, #circulating tumor cells, #Dr. Minetta Liu, #Individualizing Medicine 2017, #liquid biopsies, Advanced Cancer, breast cancer, cancer, cancer screening
May 23, 2017
By Sharon Rosen
A picture is worth a thousand words. While that saying may be true, for the more than 50 percent of all women who have dense breast tissue, a picture from traditional, 2-D mammography may not tell the full story about whether they have breast cancer. “Breast density is like the wolf in sheep’s clothing. Both […]
Tags: #breast cancer screening, #dense breast tissue, #Dr. Deborah Rhodes, #MBI, #molecular breast imaging, #personalized therapies, #tomosynthesis, 2-D mammograms, 3-D mammograms, breast cancer, breast density, center for individualized medicine
May 19, 2017
Personalized care for aggressive breast cancers: 4 steps forward from the BEAUTY study
By Sharon Rosen
Chemotherapy substantially reduces the chance that certain types of breast cancer will return or spread to other parts of the body and improves survival. Chemotherapy before surgery is a standard approach to treat women with aggressive breast cancer. However, chemotherapy does not shrink tumors in all women. Mayo Clinic researchers are turning to genomic sequencing […]
Tags: #aggressive breast cancer, #chemotherapy-resistant cancer, #patient derived xenografts, #PDX, #personalized therapies, #xenografts, Beauty Study, biomarkers, breast cancer, center for individualized medicine, chemotherapy, DNA Sequencing
May 17, 2017
By Sharon Rosen
New perspectives lead to new, groundbreaking discoveries. That’s why Mayo Clinic and the Center for Individualized Medicine support young investigators and the fresh thinking they bring to research. The Gerstner Family Foundation supports young investigators Thanks to the Gerstner Family Foundation’s support, Betty Y.S. Kim, M.D., Ph.D., a neurosurgeon and neuroscientist at Mayo Clinic’s Florida […]
Tags: #CIMCon17, #Dr. Betty Kim, #Gerstner Family Career Development Award, #nanoparticles, #Nature Nanotechnology, breast cancer, cancer, center for individualized medicine, Gerstner Family Foundation, mayo clinic, medical research