Items Tagged ‘genomics’

June 29, 2022

Mayo study validates threshold to determine when an antidepressant is ineffective

By Susan Murphy Susan Murphy (@susanmurphy)

Mayo Clinic researchers have validated a threshold designed to help determine if an antidepressant used for depression is working, but not well enough to be continued.

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Tags: #Dr. William Bobo, antidepressants, center for individualized medicine, depression, genomics, individualized medicine, major depressive disorder, medical research, personalized medicine


June 21, 2022

Scientists unravel genetic mystery of rare neurodevelopmental disorder, provide definitive diagnoses to 21 families worldwide

By Susan Murphy Susan Murphy (@susanmurphy)

A collaborative team of scientists led by Mayo Clinic’s Center for Individualized Medicine has discovered 15 additional genetic mutations in the KCNK9 gene that cause a neurodevelopmental syndrome. Symptoms of the disorder range from speech and motor impairment to behavioral abnormalities, intellectual disability and distinctive facial features.

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Tags: #neurological disorders, center for individualized medicine, Dr. Margot Cousin, gene sequencing, genomics, medical research, personalized medicine


May 26, 2022

Molecular mapping of the heart to predict disease susceptibility

By Susan Buckles Susan Buckles (@susanbuckles)

Vulnerability to heart disease can be projected before symptoms occur, Mayo Clinic discovered in preclinical research. This proof-of-concept study revealed that heart muscle changes indicate who is vulnerable to disease later in life. These changes can be detected from blood samples through comprehensive protein and metabolite profiling. This exploratory mapping, conducted in the Marriott Family […]

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Tags: Cardiovascular Disease, center for individualized medicine, Center for Regenerative Medicine, genomics, Heart Disease, individualized medicine


May 9, 2022

Mayo patient with life-threatening multidrug-resistant infection treated with experimental phage therapy combined with surgery  

By Susan Murphy Susan Murphy (@susanmurphy)

Mark Pearce, 61, was facing a possible limb amputation, even death, when a multidrug-resistant bacterial infection within his prosthetic hip replacement device started raging in his bloodstream. With his fever soaring to more than 105 degrees, Mark was taken by ambulance, that day in spring of 2020, to Mayo Clinic Hospital in Rochester, Minnesota. 

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Tags: #bacterial infections, bacteria, bacteriophage therapy, center for individualized medicine, Dr. Gina Suh, Dr. Mark Pagnano, genomics, individualized medicine, infectious disease, personalized medicine, phage therapy


May 5, 2022

Mayo research using DNA to catch cancer, other medical conditions earlier

By Adam Harringa Adam Harringa (@harringaadam)

What would happen if a certain percentage of serious medical conditions, including cancer diagnoses, were found significantly earlier by studying the entire genome of patients’ DNA? How would their quality of life improve, and how many fewer cancer deaths would there be each year? That’s what a group of Mayo Clinic scientists and clinicians aim […]

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Tags: center for individualized medicine, DNA Testing, genomics, individualized medicine, mayo clinic, medical research


April 19, 2022

Iftikhar Kullo, M.D. to serve on National Advisory Council on Human Genome Research

By Colette Gallagher Colette Gallagher (@colettegallagher)

Iftikhar Kullo, MD., has been invited to serve on the National Advisory Council on Human Genome Research (NACHGR) of the National Institutes of Health (NIH), by the Hon’ble Xavier Becerra, Secretary of the Department of Health and Human Services (DHHS), for a term beginning immediately and ending September 30, 2024. The Council advises the DHHS, the […]

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Tags: center for individualized medicine, DNA Testing, Dr. Iftikhar Kullo, gene sequencing, Genetics, genomics, individualized medicine, medical research


April 13, 2022

Mayo Clinic researchers load CAR-T cells with oncolytic virus to treat solid cancer tumors

By Susan Murphy Susan Murphy (@susanmurphy)

Researchers at Mayo Clinic’s Center for Individualized Medicine have devised an immunotherapy technique that combines chimeric antigen receptor-T cell therapy, or CAR-T cell therapy, with a cancer-killing virus to more effectively target and treat solid cancer tumors. 

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Tags: #CAR T-cell therapy, center for individualized medicine, Dr. Richard Vile, genomics, individualized medicine, medical research, oncolytic virus, personalized medicine


March 21, 2022

Mayo Clinic discovery in bone marrow cancer points to potential drug targets 

By Susan Murphy Susan Murphy (@susanmurphy)

New research from Mayo Clinic’s Center for Individualized Medicine finds that patients with ASXL1-mutant chronic myelomonocytic leukemia — an uncommon type of cancer of the bone marrow — have distinctive epigenetic changes that can activate harmful genes and cause the cancer to grow faster. The ASXL1 genetic mutation also can transform the disease into the more aggressive acute myeloid leukemia. […]

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Tags: #acute myeloid leukemia, #chronic myelomonocytic leukemia, center for individualized medicine, genomic medicine, genomics, medical research


March 16, 2022

Mayo Clinic researchers use AI to predict antidepressant outcomes in youth

By Colette Gallagher Colette Gallagher (@colettegallagher)

Mayo Clinic researchers have taken the first step in using artificial intelligence (AI) to predict early outcomes with antidepressants in children and adolescents with major depressive disorder, in a study published in The Journal of Child Psychology and Psychiatry.

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Tags: center for individualized medicine, genomics, individualized medicine, mayo clinic, medical research, personalized medicine


March 11, 2022

Nanopore sequencing method rapidly detects, identifies antibiotic-resistant microbes, Mayo Clinic research shows 

By Susan Murphy Susan Murphy (@susanmurphy)

A growing number of people are dying from antibiotic-resistant infections. These infections are fueled by microbial species that are mutating to evade the drugs developed to destroy them. More than 1.2 million people worldwide died in 2019 from antibiotic-resistant infections.  In response, a team of researchers from Mayo Clinic’s Center for Individualized Medicine has developed […]

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Tags: antibiotic-resistant, bacteria, center for individualized medicine, Genetics, genomics, infectious disease, personalized medicine


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