Items Tagged ‘George Vasmatzis’

June 2, 2015

Biomarker Discovery Program Develops New Test to Differentiate Multiple Primary Tumors from Metastasis in Lung Cancer Patients

By Jeff Briggs JeffreyBriggs

Biomarkers are molecular substances in the body that can be used to indicate health or disease. These biomarkers can be found in tissue, blood, urine and other body fluids. Prostate and ovarian cancers are two examples of how the use of biomarkers can lead to individualized diagnosis and treatment. A third example is lung cancer. […]

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Tags: biomarker, biomarkers, cancer, center for individualized medicine, Genome Sequencing, George Vasmatzis


Staying One Step Ahead of Cancer

December 18, 2014

Staying One Step Ahead of Cancer

By Center for Individualized Medicine samuelsmith5209

    Four researchers at Mayo Clinic combined their talents to spur a “bedside to bench” movement that takes the issues they face in the clinic back to the laboratory in the hopes of discovering biomarkers to help specific patients facing difficult medical problems. George Vasmatzis, Ph.D., co-director of Mayo Clinic’s Biomarker Discovery Program in […]

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Tags: Andrew Feldman, biomarker, biomarkers, center for individualized medicine, Dennis Wigle, DNA, DNA Sequencing, dna test, DNA Testing, gene sequencing, genetic, Genetics


Bringing Genomics From the Lab to the Patient

August 12, 2014

Bringing Genomics From the Lab to the Patient

By Center for Individualized Medicine samuelsmith5209

  Speaking at the Individualizing Medicine Conference last year, Gianrico Farrugia, M.D., Medical Director of the Center for Individualized Medicine at Mayo Clinic, gave an overview of the work being done in genomics at Mayo Clinic, and the future of health care through the Individualized Medicine Clinic. The Individualized Medicine Clinic (IM Clinic) offers genomic […]

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Tags: Biobank, Bioethics, biomarker, biomarkers, breast cancer, cancer, center for individualized medicine, DNA, DNA Sequencing, dna test, DNA Testing, exome


June 17, 2014

Biomarkers 101 Part 1

By AJ Montpetit ajmontpetit

George Vasmatzis, Ph.D., and John Cheville, M.D., co-directors of the Biomarker Program at the Center for Individualized Medicine at Mayo Clinic, introduce us to the world and work of Biomarkers. Biomarkers are molecular substances in the body that can be used to indicate health or disease. These biomarkers can be found in tissue, blood, urine […]

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Tags: biomarker, biomarkers, cancer, center for individualized medicine, DNA, dna test, DNA Testing, gene sequencing, Genetics, genome, genome science, Genome Sequencing


November 21, 2013

ASCL1 And RET Expression Defines Clinically Relevant Subgroup Of Lung Adenocarcinoma

By Center for Individualized Medicine samuelsmith5209

A recent publication, featuring the Director of the Biomarker Discovery Program at the Center for Individualized Medicine at Mayo Clinic, George Vasmatzis, examining the role of ASCL1 in the neuroendocrine differentiation of lung adenocarcinoma. The clinical significance of neuroendocrine differentiation in lung adenocarcinoma, and the most appropriate biomarkers for this assessment, has long been debated. In the […]

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Tags: ASCL1, biomarker, Biomarker Discovery, Biomarker Discovery Program, cancer, center for individualized medicine, chromogranin, DNA, George Vasmatzis, immunohistochemical, individualized medicine, Lung Cancer


October 17, 2013

Discovering Smoker’s Lung Cancer Biomarker

By AJ Montpetit ajmontpetit

Researchers at Mayo Clinic recently found that a specific pair of proteins may be a successful prognostic biomarker for identifying smoking-related lung cancers. The clinical significance of neuroendocrine (NE) differentiation in lung adenocarcinoma (AD), and the most appropriate biomarkers for this assessment, has long been debated. In the absence of a gold standard, investigators have most […]

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Tags: biomarker, biomarkers, cancer, center for individualized medicine, George Vasmatzis, Lung Cancer, Personal Care, Personal Medicine, personalized care, personalized medicine, Smoke, Smoker


September 12, 2013

New Publication from Center for Individualized Medicine

By AJ Montpetit ajmontpetit

Novel TRAF1-ALK fusion identified by deep RNA sequencing of anaplastic large cell lymphoma  Abstract Chromosomal translocations leading to expression of abnormal fusion proteins play a major role in the pathogenesis of various hematologic malignancies. The recent development of high-throughput, “deep” sequencing has allowed discovery of novel translocations leading to a rapid increase in understanding these diseases. Translocations […]

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Tags: center for individualized medicine, gene sequencing, genome, Genomic Sequencing, genomics, George Vasmatzis, individualized medicine, personalized medicine, RNA


August 1, 2013

Identification of Submicroscopic Genetic Changes and Precise Breakpoint Mapping in Myelofibrosis Using High Resolution Mate-Pair Sequencing

By Center for Individualized Medicine samuelsmith5209

  In a recently published article in Hemotology, Center for Individualized Medicine faculty George Vasmatzis, Ph.D., co-authored a study in high resolution mate-pair sequencing. With the use of high resolution mate-pair sequencing (HRMPS) in 15 patients with primary myelofibrosis (PMF): eight with normal karyotype and seven with PMF-characteristic cytogenetic abnormalities, including der(6)t(1;6)(q21–23;p21.3) (n = 4), der(7)t(1;7)(q10;p10) (n = 2), […]

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Tags: center for individualized medicine, genetic, genome, George Vasmatzis, individualized medicine, mate-pair, mate-pair sequencing, myelofibrosis, personalized medicine, whole genome sequencing


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