Items Tagged ‘medical research’


November 19, 2018

Gene therapy: potential and pitfalls

By Susan Buckles susanbuckles

Research is advancing gene therapy as a possible treatment or eventual cure for genetic diseases that bedevil modern science. Gene therapy was conceived over 20 years ago, and until recently, remained largely in the research lab. But gene therapy products are now beginning to be approved by the U.S. Food and Drug Administration for clinical […]

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Tags: #Brittle bone disease, #CAR T-cell therapy, #Dr. David Deyle, #gene therapy, Dr. Saad Kenderian, Mayo Clinic Center for Individualized Medicine, medical research


November 5, 2018

Pharmacogenomics: finding the right drug, dose for cancer therapy

By Sharon Rosen sharonhrosen

Each year, nearly 300,000 patients receive the lifesaving chemotherapy 5-fluorouracil (5-FU) to treat many types of cancer, including colorectal, breast, bowel, skin, pancreatic, and esophageal cancer. While it can be an effective treatment, it doesn’t work for everyone. In fact, up to 30 percent of those who receive the standard dose can have serious, life-threatening […]

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Tags: #5-fluorouracil, #5-FU chemotherapy, #chemotherapy side effects, #DPYD gene, #drug-gene interactions, #gene verifier model, breast cancer, chemotherapy, colorectal cancer, mayo clinic, Mayo Clinic Cancer Center, Mayo Clinic Center for Individualized Medicine


October 15, 2018

Personalized screening: finding and treating breast cancer sooner

By Sharon Rosen sharonhrosen

October is Breast Cancer Awareness Month, a time to reflect on new, individualized approaches to detecting and treating a cancer that affects 1 in 8 American women. Deborah Rhodes, M.D. and her Mayo Clinic colleagues are working to identify the best targeted screening tools and guidelines for women with a higher risk of developing breast […]

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Tags: #breast cancer screening, #dense breast tissue, #Dr. Deborah Rhodes, #Dr. Michael O'Connor, #Dr. Myra Wick, #molecular breast imaging, 3-D mammograms, breast cancer, breast density, center for individualized medicine, Dr. Carrie Hruska, mayo clinic


October 4, 2018

Meet Lisa Schimmenti: Searching for drug therapies to treat hearing loss

By Sharon Rosen sharonhrosen

Lisa Schimmenti, M.D. has always been fascinated with Helen Keller and all she accomplished, in spite of being blind and deaf from a very young age. As the newly appointed chair of Mayo Clinic’s Department of Clinical Genomics and a medical geneticist, Dr. Schimmenti cares for patients with similar conditions. In her clinical practice, she sees […]

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Tags: #Dr. Lisa Schimmenti, #drug discovery, #hearing aids, #hearing loss, #Mayo Clinic Department of Clinical Genomics, #Mayo Clinic Department of Otorhinolaryngology, #Usher Syndrome, #zebrafish, center for individualized medicine, mayo clinic, medical research


September 4, 2018

Preemptive genetic testing: could it help you take charge of your health?

By Sharon Rosen sharonhrosen

A blood pressure check, an immunization and a cholesterol test – these are all parts of your routine medical care. Someday, a genetic test to identify your risk for developing disease may also be added to the list. In fact, researchers believe that day is fast approaching thanks to the rapid advances in genomic medicine. […]

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Tags: #CIMCon18, #DNA sequencing tests, #Mayo Clinic Biobank, #pre-emptive genetic testing, center for individualized medicine, Dr. Konstantinos Lazaridis, Genetic Testing, mayo clinic, medical research, whole genome sequencing


August 20, 2018

Preparing the next generation – interns engaged in precision medicine research

By Sharon Rosen sharonhrosen

When Zachary Stephens started his summer internship at Mayo Clinic in 2013, he was thrust into a world where solving big data challenges can lead to more individualized care for patients. As a graduate student in electrical and computer engineering at the University of Illinois at Urbana-Champaign, he was used to developing computer models to analyze […]

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Tags: #CIMCon18, #Dr. Jean Pierre Kocher, #information technology, #IT, #Mayo Clinic & Illinois Alliance for Technology-based Healthcare, #Mayo Clinic Graduate School of Biomedical Sciences, #medical education, #summer undergraduate research fellowship, #University of Illinois at Urbana Champaign (Illinois), #Zachary Stephens, Bioinformatics, Caer Rohrer Vitek


August 6, 2018

Unlocking the power of genomics data: course offers new tools for discovery

By Sharon Rosen sharonhrosen

Michelle Cox was among the medical students and trainees, research fellows and laboratory staff who recently gathered to attend this year’s Computational Genomics Course, sponsored by the Mayo Clinic and Illinois Alliance for Technology-Based Healthcare. Even before the week-long course ended, Cox, a research technologist in the Mayo Clinic Division of Hematology, was sharing what […]

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Tags: #CIMCon18, #computational genomics, #Computational Genomics Course, #Dr. Krishna Kalari, #genomics analysis, #Genomics data, #Mayo Clinic and Illinois Alliance for Technology-Based Healthcare, #medical education, #Michael Kalmbach, #Michelle Cox, #University of Illinois at Urbana Champaign (Illinois), center for individualized medicine


July 30, 2018

Tool of the trade: researcher applies artificial intelligence to uncover causes, risks for disease

By Sharon Rosen sharonhrosen

Some diseases, such as certain breast and colon cancers, are linked to genetic mutations passed down in families. But for many other diseases there are no direct genetic links that explain why the disease develops. That’s why Manolis Kellis, Ph.D. and his team are using artificial intelligence to uncover the hidden cause of disease. Dr. […]

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Tags: #CIMCon18, #computational genetics, #Dr. Manolis Kellis, #Dr. Tamas Ordog, #Individualizing Medicine 2018, #Massachusetts Institute of Technology, #mathematical models, #Mayo Clinic Center for Individualized Medicine Epigenomics Program, #MIT Computational Biology Group, #obesity, Alzheimer’s disease, center for individualized medicine


June 21, 2018

Taking action: using pharmacogenomics testing to individualize care for colorectal cancer

By Sharon Rosen sharonhrosen

Every day, Pashtoon Kasi, M.D., M.B.B.S. is inspired by his patients with colorectal cancer to deliver the best, individualized care to meet their unique needs. As an oncologist at Mayo Clinic’s campus in Florida, Dr. Kasi is seeing many of the growing number of younger patients – those in their 20’s, 30’s and 40’s – diagnosed with […]

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Tags: #CIMCon18, #clinical research, #drug-gene interactions, #Individualizing Medicine 2018, #medication side effects, #pharmacogenomics testing, #pre-emptive pharmacogenomics testing, center for individualized medicine, chemotherapy, colorectal cancer, Genetic Testing, mayo clinic


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