Items Tagged ‘personalized medicine’

February 2, 2023

A rare genetic cause for a common medical condition

By Susan Murphy Susan Murphy (@susanmurphy)

By Michael Clayton Genetic testing for inherited conditions is performed on a patient’s DNA taken from either blood, saliva or, rarely, skin biopsy. This information from a person’s DNA can provide diagnostic workup of rare inherited conditions. And together with a comprehensive personal and family history, it can help patients understand how a genetic disorder may affect them and their family. Diagnosed with diabetes more […]

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Tags: center for individualized medicine, gene sequencing, genomics, personalized medicine


January 24, 2023

Could antidepressants cause treatment-emergent mania?

By Colette Gallagher Colette Gallagher (@colettegallagher)

In a study published in Molecular Psychiatry, Mark Frye, M.D., a Mayo Clinic researcher and collaborators, investigated the risk of treatment-emergent mania in bipolar disorder when treated with antidepressants. “We found that antidepressants that increase mitochondrial energetics (cells that extract energy from nutrients for sustaining life) may elevate the risk of treatment-emergent mania,” says Dr. […]

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Tags: center for individualized medicine, mayo clinic, personalized medicine


January 4, 2023

Advancing precision and predictive medicine in rheumatoid arthritis

By Susan Murphy Susan Murphy (@susanmurphy)

By Alumni Magazine Most patients who are diagnosed with rheumatoid arthritis respond to either the first or second line of drug therapies. However, some patients try multiple drugs without improve ment in their condition. It can take as long as two years of suffering, disease progression and expense before landing on a medication they respond to. […]

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Tags: center for individualized medicine, gene sequencing, genomic medicine, personalized medicine, Rheumatoid Arthritis


December 28, 2022

3 impactful Mayo Clinic cancer research studies of 2022

By Susan Murphy Susan Murphy (@susanmurphy)

In 2022, Mayo Clinic physicians and scientists interrogated the genome, exome, proteome, epigenome, exposome, transcriptome and more with remarkable depth to shed new light on the hidden biological signatures of cancer. Using artificial intelligence and a wealth of multi-omics data, the pioneering teams of researchers worked side by side to pave a path for potential […]

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Tags: center for individualized medicine, Genetics, genomic medicine, personalized medicine


December 22, 2022

Genetic counseling after cancer diagnosis

By Susan Murphy Susan Murphy (@susanmurphy)

By Cynthia Weiss DEAR MAYO CLINIC: I was diagnosed with ovarian cancer two months ago. My oncologist recommended that I undergo genetic testing as part of the treatment plan. Why is this recommended since I already have cancer? What is the benefit of testing? And what information will it provide? ANSWER: Genetic counseling can be an important part […]

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Tags: center for individualized medicine, DNA Testing, gene sequencing, Genetics, genomics, personalized medicine


November 18, 2022

New tool brings Mayo Clinic researchers closer to discovering therapeutics from microbiome

By Susan Murphy Susan Murphy (@susanmurphy)

Does the human microbiome inhabit a natural pharmacy? Microorganisms are found in tissues and biofluids throughout the body, including in and around the gut, lungs, nose, mouth, skin and vagina. A flurry of recent scientific research suggests that this human microbiome — a community of trillions of bacteria, viruses and fungi — is a driver […]

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Tags: #Dr. Jaeyun Sung, center for individualized medicine, genomic medicine, personalized medicine


October 18, 2022

Novel suppression-replacement preclinical gene therapy study shows promise in long and short QT syndromes

By Colette Gallagher Colette Gallagher (@colettegallagher)

In a new study published in Circulation: Genomics & Precision Medicine, Mayo Clinic researchers designed and developed the first suppression-replacement KCNH2 gene therapy for correcting both long QT syndrome (LQTS) and short QT syndrome (SQTS). LQTS is a genetic heart disease that can potentially cause fast, chaotic heartbeats. These rapid heartbeats might trigger people to […]

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Tags: center for individualized medicine, gene therapy, genomic medicine, individualized medicine, mayo clinic, personalized medicine


October 4, 2022

Mayo study lays foundation to predict antidepressant response in people with suicide attempts

By Susan Murphy Susan Murphy (@susanmurphy)

Mayo Clinic researchers have discovered that people with major depressive disorder and a history of attempted suicide have distinct biomarkers that correlate with their response to antidepressant therapy. The new findings, published in Frontiers Pharmacology, are key to individualized treatment strategies and early identification of patients who are at the highest risk for suicide.   For […]

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Tags: center for individualized medicine, depression, genomics, major depressive disorder, personalized medicine


September 15, 2022

Designing Personalized Vaccines to Combat Cancer

By Susan Murphy Susan Murphy (@susanmurphy)

Mayo Clinic researchers are working to develop personalized therapeutic cancer vaccines that can potentially target each person’s distinctive tumor characteristics. The new approach, built on advances in genomic research and data analytics, holds transformative potential to boost the power of the immune system to identify and attack cancer cells. 

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Tags: Cancer Research, cancer vaccine, center for individualized medicine, Genetics, medical research, neoantigen, personalized medicine


August 1, 2022

New AI algorithm opens avenues for knowledge discoveries

By Colette Gallagher Colette Gallagher (@colettegallagher)

In a proof-of-concept study published in Frontiers in Immunology, Hu Li, Ph.D., a Mayo Clinic Center for Individualized Medicine systems biologist, developed a new artificial intelligence (AI) algorithm which uses novel weight engineering methods to extract meaningful biological knowledge learned by AI models. He and his team applied the tool to breast cancer omic data […]

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Tags: Cancer Research, center for individualized medicine, individualized medicine, mayo clinic, personalized medicine


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