Items Tagged ‘pharmacogenomics’

April 23, 2019

Editorial: Why DNA sequencing is an effective tool for patient care

By Colette Gallagher colettegallagher

By Keith Stewart, M.B., CH.B. For the past 30 years, I’ve been fortunate enough to work with and help many patients. But over that time, I’ve also met people who did not respond to therapy or had significant side effects, while others had marvelous responses. Cases like these show a clear need for personalized medicine. […]

View full entry

Tags: #rare and undiagnosed diseases, DNA Sequencing, Dr. Keith Stewart, Mayo Clinic Center for Individualized Medicine, pharmacogenomics, undiagnosed disease


Novel data-driven approach for precision medicine

November 12, 2018

Novel data-driven approach for precision medicine

By Colette Gallagher colettegallagher

Thousands of patients’ tumors have been sequenced in the past decade, yielding a rich source of data on the changes associated with the cancer development and treatment response. However, there are no validated methods that are used in the clinic to select the best therapy. Today, Mayo Clinic researchers report an omics-guided (comprehensive) drug prioritization […]

View full entry

Tags: #Dr. Krishna Kalari, Dr. Judy Boughey, Dr. Liewei Wang, Dr. Matthew Goetz, Mayo Clinic Center for Individualized Medicine, personal genomics, pharmacogenomics


November 5, 2018

Pharmacogenomics: finding the right drug, dose for cancer therapy

By Sharon Rosen sharonhrosen

Each year, nearly 300,000 patients receive the lifesaving chemotherapy 5-fluorouracil (5-FU) to treat many types of cancer, including colorectal, breast, bowel, skin, pancreatic, and esophageal cancer. While it can be an effective treatment, it doesn’t work for everyone. In fact, up to 30 percent of those who receive the standard dose can have serious, life-threatening […]

View full entry

Tags: #5-fluorouracil, #5-FU chemotherapy, #chemotherapy side effects, #DPYD gene, #drug-gene interactions, #gene verifier model, breast cancer, chemotherapy, colorectal cancer, mayo clinic, Mayo Clinic Cancer Center, Mayo Clinic Center for Individualized Medicine


June 25, 2018

Research suggests genetics are key in treating night sweats

By Susan Buckles susanbuckles

Article by Heather Carlson Women going through menopause know all too well the discomfort associated with night sweats. Hormone therapy is often used to prevent night sweats. But finding the right dose of estrogen can be tricky, with some women needing more estrogen than others to get relief. Why the difference in how women respond […]

View full entry

Tags: Dr. Ann Moyer, Dr. Richard Weinshilboum, Dr. Virginia Miller, Mayo Clinic Center for Individualized Medicine, Mayo Clinic Women's Health Research Center, Menopause, Night sweats, pharmacogenomics


June 21, 2018

Taking action: using pharmacogenomics testing to individualize care for colorectal cancer

By Sharon Rosen sharonhrosen

Every day, Pashtoon Kasi, M.D., M.B.B.S. is inspired by his patients with colorectal cancer to deliver the best, individualized care to meet their unique needs. As an oncologist at Mayo Clinic’s campus in Florida, Dr. Kasi is seeing many of the growing number of younger patients – those in their 20’s, 30’s and 40’s – diagnosed with […]

View full entry

Tags: #CIMCon18, #clinical research, #drug-gene interactions, #Individualizing Medicine 2018, #medication side effects, #pharmacogenomics testing, #pre-emptive pharmacogenomics testing, center for individualized medicine, chemotherapy, colorectal cancer, Genetic Testing, mayo clinic


June 12, 2018

Harnessing the power of big data to uncover genetic risk for disease

By Sharon Rosen sharonhrosen

There is no single gene that causes diabetes, bipolar disorder or Alzheimer’s disease, but there are genes linked to conditions that may occur before a patient eventually develops these disorders. What if researchers could identify individuals whose genetic makeup puts them at risk for developing disease so that physicians could intervene sooner and provide more […]

View full entry

Tags: #bipolar disorder, #CIMCon18, #computational genetics, #diabetes, #Dr. Nany Cox, #genetic data analysis, #Individualizing Medicine 2018, #Vanderbilt University Biobank, Alzheimer’s disease, Biobank, center for individualized medicine, DNA Sequencing


April 16, 2018

15 ways genomics is impacting our lives: Genomic literacy and pharmacogenomics

By Susan Buckles susanbuckles

To apply important genomic research at the point of care, medical providers and patients must first understand it. That fact spotlights the need for “Genomics 101” type of education to help the medical community keep up with newest discoveries. Genomic literacy – explaining scientific findings in understandable terms – is one goal of the ‘15 […]

View full entry

Tags: 15for15, DNA Day 18, DNA Sequencing, Dr. Richard Weinshilboum, Dr. Timothy Curry, Genetic Testing, Genetics, Genomic literacy, genomics, GLEE initiative, Human Genome Project, individualized medicine


April 3, 2018

Registration opens for Individualizing Medicine 2018 Conference

By Sharon Rosen sharonhrosen

Gene editing, artificial intelligence, pharmacogenomics and a new era of genomic testing to identify and hopefully treat inherited cancer are just a few of the emerging areas of precision medicine that have the potential to transform patient care. These are among the hot topics in precision medicine experts from Mayo Clinic and around the world […]

View full entry

Tags: #Artificial Intelligence, #CIMCon18, #Dr. Eric Green, #Dr. Heidi Rehm, #genomic testing, #Individualizing Medicine Conference: Advancing Care Through Genomics, #personalized diet, #prenatal testing, #rare and undiagnosed diseases, center for individualized medicine, Dr. Timothy Curry, gene editing


March 20, 2018

Mayo’s RIGHT 10K – moving pharmacogenomics into everyday clinical practice

By Sharon Rosen sharonhrosen

After nearly half a century of research, Mayo Clinic is a leader in moving pharmacogenomics into clinical practice. This year pharmacogenomics test results for 10,000 Mayo Clinic patients, all participants in the RIGHT 10K study, are being added to the electronic health record. “I’ve spent my career exploring pharmacogenomics – how a person’s genetics affect […]

View full entry

Tags: #CIMCon18, #DNA sequencing tests, #Dr. Paul Takahashi, #drug-gene interactions, #pharmacogenomic testing, #RIGHT 10K, center for individualized medicine, DNA, Dr. Richard Weinshilboum, genomics, mayo clinic, medical research


February 27, 2018

Pharmacogenomic testing helps children with acid reflux disease find relief

By Sharon Rosen sharonhrosen

Many people have occasional acid reflux or heartburn after eating a heavy or spicy meal. But for children and adults with acid reflux disease, also known as gastroesophageal reflux disease (GERD), the symptoms are more frequent and severe. These patients often experience vomiting, diarrhea and persistent burning in their stomach after eating. Many also experience […]

View full entry

Tags: #acid reflux disease, #anti-acid therapy, #Clinomics Program, #Dr. Imad Absah, #gastroesophageal reflux disease, #GERD, #PGx pilot study, #PGx testing, #pharmacogenomic testing, center for individualized medicine, DNA Testing, Genetic Testing


Contact Us · Privacy Policy