Items Tagged ‘pharmacogenomics’

September 25, 2019

The BEAUTY of it: award recognizes personalized medicine approach for breast cancer

By Barbara J. Toman Barbara J. Toman

A Mayo Clinic research team supported by the Center for Individualized Medicine is making significant breakthroughs — and gaining recognition for them. The Breast Cancer Genome-Guided Therapy (BEAUTY) project has received the 2019 Mayo Clinic Team Science Award, given for interdisciplinary work that substantially advances Mayo’s research. The award cites BEAUTY’s discoveries about breast tumor […]

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Tags: #targeted therapies, BEAUTY trial, breast cancer, center for individualized medicine, chemotherapy, chemotherapy-resistant breast cancer, Dr. Judy Boughey, Dr. Liewei Wang, Dr. Matthew Goetz, Genetics, genomics, individualized medicine


July 25, 2019

Antoni Ribas, M.D., Ph.D. – leading melanoma researcher to speak at #CIMCON19

By Sharon Rosen Sharon Rosen

Article by Sara Damore Melanoma is an aggressive skin cancer caused by extensive sun exposure and the fifth most common cancer in the U.S. If detected and treated early, the survival rates for melanoma are high (98%). However, once the cancer spreads to other areas of the body, survival rates for malignant melanoma drop dramatically […]

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Tags: #CIMCon19, #skin cancer, BRAF gene, center for individualized medicine, Dr. Antoni Ribas, geenetics, genomics, Herpes virus, immunotherapy, individualized medicine, mayo clinic, Melanoma


July 9, 2019

Mayo experts provide insights into how genes affect medication response

By Sharon Rosen Sharon Rosen

Pharmacogenomics – how a person’s genes affect medication response – is touching virtually every area of medical care.  Findings from the Mayo Clinic RIGHT study (Right Drug, Right Dose, Right Time–Using Genomic Data to Individualize Treatment) showed that 99% of participants had at least one genetic variant that may affect their response to medications.    […]

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Tags: #addiction, #anti-seizure medication, #Center for Individualized Mediicine, #Dr. Lauren Cornell, #Dr. Sanjay Bagaria, #Dr. William Freeman, #Dr. William Palmer, #drug-gene interactions, #epilepsy, #estrogen receptor positive breast cancer, #medical education, #neurological diseases


April 23, 2019

Editorial: Why DNA sequencing is an effective tool for patient care

By Colette Gallagher Colette Gallagher

By Keith Stewart, M.B., CH.B. For the past 30 years, I’ve been fortunate enough to work with and help many patients. But over that time, I’ve also met people who did not respond to therapy or had significant side effects, while others had marvelous responses. Cases like these show a clear need for personalized medicine. […]

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Tags: #rare and undiagnosed diseases, DNA Sequencing, Dr. Keith Stewart, Mayo Clinic Center for Individualized Medicine, pharmacogenomics, undiagnosed disease


Novel data-driven approach for precision medicine

November 12, 2018

Novel data-driven approach for precision medicine

By Colette Gallagher Colette Gallagher

Thousands of patients’ tumors have been sequenced in the past decade, yielding a rich source of data on the changes associated with the cancer development and treatment response. However, there are no validated methods that are used in the clinic to select the best therapy. Today, Mayo Clinic researchers report an omics-guided (comprehensive) drug prioritization […]

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Tags: #Dr. Krishna Kalari, Dr. Judy Boughey, Dr. Liewei Wang, Dr. Matthew Goetz, Mayo Clinic Center for Individualized Medicine, personal genomics, pharmacogenomics


November 5, 2018

Pharmacogenomics: finding the right drug, dose for cancer therapy

By Sharon Rosen Sharon Rosen

Each year, nearly 300,000 patients receive the lifesaving chemotherapy 5-fluorouracil (5-FU) to treat many types of cancer, including colorectal, breast, bowel, skin, pancreatic, and esophageal cancer. While it can be an effective treatment, it doesn’t work for everyone. In fact, up to 30 percent of those who receive the standard dose can have serious, life-threatening […]

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Tags: #5-fluorouracil, #5-FU chemotherapy, #chemotherapy side effects, #DPYD gene, #drug-gene interactions, #gene verifier model, breast cancer, chemotherapy, colorectal cancer, mayo clinic, Mayo Clinic Cancer Center, Mayo Clinic Center for Individualized Medicine


June 25, 2018

Research suggests genetics are key in treating night sweats

By Susan Buckles Susan Buckles

Article by Heather Carlson Women going through menopause know all too well the discomfort associated with night sweats. Hormone therapy is often used to prevent night sweats. But finding the right dose of estrogen can be tricky, with some women needing more estrogen than others to get relief. Why the difference in how women respond […]

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Tags: Dr. Ann Moyer, Dr. Richard Weinshilboum, Dr. Virginia Miller, Mayo Clinic Center for Individualized Medicine, Mayo Clinic Women's Health Research Center, Menopause, Night sweats, pharmacogenomics


June 21, 2018

Taking action: using pharmacogenomics testing to individualize care for colorectal cancer

By Sharon Rosen Sharon Rosen

Every day, Pashtoon Kasi, M.D., M.B.B.S. is inspired by his patients with colorectal cancer to deliver the best, individualized care to meet their unique needs. As an oncologist at Mayo Clinic’s campus in Florida, Dr. Kasi is seeing many of the growing number of younger patients – those in their 20’s, 30’s and 40’s – diagnosed with […]

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Tags: #CIMCon18, #clinical research, #drug-gene interactions, #Individualizing Medicine 2018, #medication side effects, #pharmacogenomics testing, #pre-emptive pharmacogenomics testing, center for individualized medicine, chemotherapy, colorectal cancer, Genetic Testing, mayo clinic


June 12, 2018

Harnessing the power of big data to uncover genetic risk for disease

By Sharon Rosen Sharon Rosen

There is no single gene that causes diabetes, bipolar disorder or Alzheimer’s disease, but there are genes linked to conditions that may occur before a patient eventually develops these disorders. What if researchers could identify individuals whose genetic makeup puts them at risk for developing disease so that physicians could intervene sooner and provide more […]

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Tags: #bipolar disorder, #CIMCon18, #computational genetics, #diabetes, #Dr. Nany Cox, #genetic data analysis, #Individualizing Medicine 2018, #Vanderbilt University Biobank, Alzheimer’s disease, Biobank, center for individualized medicine, DNA Sequencing


April 16, 2018

15 ways genomics is impacting our lives: Genomic literacy and pharmacogenomics

By Susan Buckles Susan Buckles

To apply important genomic research at the point of care, medical providers and patients must first understand it. That fact spotlights the need for “Genomics 101” type of education to help the medical community keep up with newest discoveries. Genomic literacy – explaining scientific findings in understandable terms – is one goal of the ‘15 […]

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Tags: 15for15, DNA Day 18, DNA Sequencing, Dr. Richard Weinshilboum, Dr. Timothy Curry, Genetic Testing, Genetics, Genomic literacy, genomics, GLEE initiative, Human Genome Project, individualized medicine


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