Items Tagged ‘RNA sequencing’
October 23, 2019
Finding the needle in the haystack: a tool for rare inherited diseases
Individualized medicine has had notable success in identifying DNA mutations that cause cancer. But rare inherited diseases pose an even bigger challenge. Like a needle in a haystack, the cause of a rare inherited disease is often deeply buried, in the DNA that comprises genes or controls their expression. Now however, Mayo Clinic’s Center for […]
Tags: #Gavin Oliver, biioinformatics, center for individualized medicine, fusion transcript detection, fusion transcription, Genetic Testing, genomics, inherited rare diseases, mayo clinic, RNA sequencing
September 12, 2018
CIM CON day 1 – Precision cancer care: ‘So much power’
Article by Barbara Toman Unlocking the secrets of the genetic blueprint may hold the key to both detecting and effectively treating cancer. Researchers from around the world are discussing new ways to diagnose and treat cancer at the Individualizing Medicine Conference: Advancing Care through Genomics, which started today. The Mayo Clinic Center for Individualized Medicine (CIM) […]
Tags: #CAR T-cell therapy, #CIMCon18, #Dr. Mike Berger, #Dr. Yi Lin, #Indvidualizing Medicince Conference, cancer genomics, Genomic Sequencing, Mayo Clinic Center for Individualized Medicine, RNA sequencing
November 2, 2017
Researchers at Mayo Clinic Center for Individualized Medicine have uncovered genetic clues to why tumors resist a specific therapy used for treating advanced prostate cancer. This discovery can guide health care providers to individualized treatments for castration-resistant prostate cancer, a deadly disease that does not respond to standard hormone therapy. Several U.S. Food and Drug […]
Tags: Advanced prostate cancer, castration-resistant prostate cancer, center for individualized medicine, Dr. Keith Stewart, Dr. Liewei Wang, Dr. Manish Kohli, individualized medicine, medical research, personalized medicine, Precision Medicine, Prostate Cancer, RNA sequencing
May 19, 2017
Personalized care for aggressive breast cancers: 4 steps forward from the BEAUTY study
By Sharon Rosen 
Chemotherapy substantially reduces the chance that certain types of breast cancer will return or spread to other parts of the body and improves survival. Chemotherapy before surgery is a standard approach to treat women with aggressive breast cancer. However, chemotherapy does not shrink tumors in all women. Mayo Clinic researchers are turning to genomic sequencing […]
Tags: #aggressive breast cancer, #chemotherapy-resistant cancer, #patient derived xenografts, #PDX, #personalized therapies, #xenografts, Beauty Study, biomarkers, breast cancer, center for individualized medicine, chemotherapy, DNA Sequencing
November 8, 2016
Early Career Investigators Share Their Research and Their Passion for Precision Medicine
By Sharon Rosen
Six early career investigators presented a snapshot of the future of precision medicine as part of the Individualizing Medicine Conference 2016: Advancing Care Through Genomics. Thanks to generous support from the Brandt Family Scholars Fund, the six had the opportunity to attend the conference Mayo Clinic Center for Individualized Medicine hosted in October in Rochester, Minn. […]
Tags: #Brandt Family Scholars, #CIMCon16, #DNA anlysis, #Dr. Chelsea Gawryletz, #Dr. Irina St. Louis, #Dr. Laura Ramsey, #Early career investigators, #Genomics data, #Genomics research, Arjun Athreya, center for individualized medicine, Dr. Nicole Boczek
March 11, 2016
RNA Sequencing Analysis for the Diagnosis of Oral Facial Digital Syndrome
By Jeff Briggs
Whole-exome sequencing has become an extremely valuable tool in the diagnoses of rare diseases, of which 80 percent can have an underlying genetic cause. Earlier this week we ran the story of a study from the Center for Individualized Medicine that recommended whole-exome sequencing as a viable option in diagnostic odyssey cases of rare diseases. […]
Tags: ACMG, American College of Medical Genetics and Genomics, center for individualized medicine, Dr. Nicole Boczek, Oral-facial-digital syndrome, RNA sequencing, WES, whole exome sequencing