October 30th, 2014 · Leave a Comment

The Future of Individualized Medicine at Mayo Clinic

By Center for Individualized Medicine

The Future of Individualized Medicine at Mayo Clinic

 

Individualizing Medicine 2014: From Promise to Practice, was held in October in Rochester, focusing on how to translate the promise of genomic medicine into practice. Expert speakers, focused breakout sessions, real-life case studies and a poster session provided attendees with many opportunities to discover and discuss emerging topics in applied genomics. Speakers covered a range of medical subjects, from cancer and rare diseases to cardiovascular medicine and obstetrics.

A few speakers below took time to answer some questions about how genomics is already transforming care at Mayo Clinic and what the future holds for this exciting [...]

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Tags: biobank, bioethics, biomarker, biomarkers, center for individualized medicine, DNA, DNA Sequencing, dna test, DNA Testing, gene sequencing, genetic, Genetics, genome, genome science, Genome Sequencing, genomic, genomic medicine, genomics, Individualized Medicine, individualized Medicine clinic, IndividualizedMedicine, Judy Boughey, Kelly Wix, Matthew Goetz, Mayo Clinic, microbiome, personal genomics, personalized care, personalized medicine, pharmacogenomics, predictive medicine, whole genome sequencing

October 28th, 2014 · Leave a Comment

Findings Reveal Relationship with TP63 & p63 Protein Expression in Lung Adenocarcinoma

By Center for Individualized Medicine

 

New Research from the Epigenomics Program

 

Using next-generation sequencing analysis of mate-pair DNA libraries, a group of researchers from the Center for Individualized Medicine recently identified novel chromosomal rearrangements involving TP63 in approximately 6% in peripheral T-cell lymphomas and demonstrated that these were associated with a poorer overall survival than lymphomas without these rearrangements. These rearrangements also were found in occasional B-cell lymphomas, but were not identified by RNA sequencing in a small series of carcinomas of the lung, breast, or head and neck. By immunohistochemistry, TP63 rearrangements were associated with a p63+/p40− profile in lymphomas. As a subset of lung adenocarcinomas has a p63+/p40− [...]

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Tags: biobank, biomarker, biomarkers, cancer, center for individualized medicine, DNA, DNA Sequencing, dna test, DNA Testing, gene sequencing, genetic, Genetics, genome, genome science, Genome Sequencing, genomic, genomic medicine, genomics, Individualized Medicine, individualized Medicine clinic, Mayo Clinic, microbiome, personal genomics, personalized care, predictive medicine, whole genome sequencing

October 23rd, 2014 · Leave a Comment

The Role of Ethics in Genomics

By Center for Individualized Medicine

 

 
Jen McCormick, Ph.D., director of the Bioethics Program for the Center for Individualized Medicine at Mayo Clinic explains the goal of the Bioethics Program, which is to ensure that the Center for Individualized Medicine is aware of and responsibly addressing the ethical, legal, policy and social issues related to genomic research, translating genomic technologies for clinical use and implementing genomic-based individualized medicine.
 
 
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Tags: bioethics, center for individualized medicine, DNA, DNA Sequencing, dna test, DNA Testing, gene sequencing, Genetics, genome, genome science, Genome Sequencing, genomic, genomic medicine, genomics, Individualized Medicine, individualized Medicine clinic, IndividualizedMedicine, Mayo Clinic, personal genomics, personalized care, personalized medicine, pharmacogenomics, predictive medicine, whole genome sequencing

October 21st, 2014 · Leave a Comment

Director of Pharmacogenomics Receives Honor From Mayo Clinic

By Center for Individualized Medicine

Richard Weinshilboum, M.D., Director of the Pharmacogenomics Program at the Center for Individualized Medicine, is being honored by the Mayo Clinic Board of Governors as a Mayo Clinic Distinguished Alumni. This is the highest award that Mayo can confer on its staff.

Dr. Weinshilboum studies pharmacogenomics — the role of inheritance and individual variation in DNA sequence or structure in drug response. The goal is to develop safer and more effective drug therapy to treat diseases that range from cancer to depression.

Dr. Weinshilboum's research program utilizes genomic techniques that include genome-wide association studies (GWAS) and "next-generation" whole genome DNA sequencing using samples from large numbers of patients treated with a specific anticancer [...]

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Tags: biomarkers, cancer, center for individualized medicine, DNA, DNA Sequencing, dna test, DNA Testing, Dr Richard Besser, gene sequencing, Genetics, genome, genome science, Genome Sequencing, genomic, genomic medicine, genomics, Individualized Medicine, Mayo Clinic, pharmacogenomics, predictive medicine, Weinshilboum, whole genome sequencing

October 15th, 2014 · Leave a Comment

Diet & Exercise Orthogonally Alter the Gut Microbiome

By Center for Individualized Medicine

New Research from the Epigenomics Program

 
And Reveal Independent Associations With Anxiety & Cognition
 

The Microbiome team at the Center for Inidivdualized Medicine of Mayo Clinic recently published a paper that found that ingestion of a high-fat diet (HFD) and the resulting obese state can exert a multitude of stressors on the individual including anxiety and cognitive dysfunction.

Though many studies have shown that exercise can alleviate the negative consequences of a HFD using metabolic readouts such as insulin and glucose, a paucity of well-controlled rodent studies have been published on HFD and exercise interactions with regard to behavioral outcomes. This is a critical issue since some [...]

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Tags: biomarker, biomarkers, center for individualized medicine, DNA, DNA Sequencing, dna test, DNA Testing, gene sequencing, genetic, Genetics, genome, genome science, Genome Sequencing, genomic, genomic medicine, genomics, Gut Microbiome, Individualized Medicine, Mayo Clinic, microbiome, personal genomics, personalized care, personalized medicine, predictive medicine, whole genome sequencing

October 14th, 2014 · Leave a Comment

A Mysterious Disease

By Center for Individualized Medicine

Jarvie Burdell

 

Article Originally found at Mayo Clinic's "You Are" Blog.

 

The genomic counselor brought good news — the Individualized Medicine Clinic team had found the culprit gene. Renata Burdell knew her son's medical odyssey was finally over.
"It has made such a huge difference," Renata says. "We don't have to keep wondering and going from one specialist to another looking for a reason for Javrie's symptoms."
In one sense, what she and her husband, Josiah Burdell, sought for their 6-year-old son, Javrie, was simple — a name for his condition. A seemingly endless parade of local caregivers failed to give [...]

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Tags: biobank, bioethics, biomarker, biomarkers, cancer, center for individualized medicine, DNA, DNA Sequencing, dna test, DNA Testing, gene sequencing, Genetics, genome, genome science, Genome Sequencing, genomic, genomic medicine, genomics, Individualized Medicine, individualized Medicine clinic, IndividualizedMedicine, Mayo Clinic, personal genomics, personalized care, personalized medicine, predictive medicine, whole genome sequencing

October 8th, 2014 · Leave a Comment

Individualizing Medicine 2014: Day Three Recap

By Sam Smith

The final day of the Individualizing Medicine 2014 Conference kicked off with one of the pioneers of genomics taking the stage. Having founded the Baylor College of Medicine Human Genome Sequencing Center in 1997, Richard Gibbs led one of the five main groups that completed the Human Genome Project. Gibbs discussed his past, present and future work at Baylor, and the impact clinical exome sequencing has had on genetic research. He has been active in Mendelian disease discovery, and discussed the limitations created by lack of sample size.

Munir Pirmohamed, M.B., Ch.B., Ph.D., the National Health Service Chair of Pharmacogenetics in the United Kingdom, presents his research on pharmacogenomics at Individualizing [...]</p/>
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Tags: Alexander Parker, Baylor College of Medicine, ceci connolly, Christopher Corless, Conference, DNA, EU-PACT, genome, genomics, Human Genome Sequencing Center, Individualized Medicine, Individualizing Medicine, individualizing medicine 2014, individualizing medicine conference, mayo clinic conference, Munir Pirmohamed, National Health Service, Peter Jones, Richard Gibbs, sequencing, Van Andel Institute

October 7th, 2014 · Leave a Comment

Individualizing Medicine 2014: Day Two Recap

By Sam Smith

Day two of the Individualizing Medicine 2014 Conference dispelled any notion of a conference on genomics being a gathering of humorless, stuffy scientists talking about the minutiae of genetic alphabet soup. Bob Dylan and Fifty Shades of Grey, Clint Eastwood and Dr. Seuss were intermixed in with informative talks that centered on the power of pharmacogenomics, the future, and challenges of the field.

Ceci Connolly, managing director of PwC's Health Research Institute, kicks off day two of Individualizing Medicine 2014: From Promise to Practice

Ceci Connolly, managing director of PwC's Health Research Institute, kicks off day two of Individualizing Medicine 2014: From Promise to Practice

Moderator Ceci Connolly introduced the [...]

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Tags: 23andMe, beauty project, ceci connolly, center for individualized medicine, Conference, dan roden, genomics, Gianrico Farrugia, im2014, Individualized Medicine, Individualized Medicine Conference, individualizing medicine 2014, individualizing medicine conference, Judy Boughey, lawrence lesko, lon cardon, Matthew Goetz, personalized medicine, rebecca nagy, Richard Weinshilboum, sequencing, tom petty

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