December 9th, 2014 · Leave a Comment

Tracing the Lineage of Lung Cancer Tumors

By Center for Individualized Medicine

 

New test distinguishes lung cancer tumors

 

A diagnostic test based on chromosomal rearrangements can trace the lineage of lung cancer to determine whether two separate lung cancers in the same patient are independent tumors or a tumor that has spread to another region of the lung, a Mayo Clinic study has found. For patients with multiple tumors, that distinction could mean the difference between early stage cancer that may be cured by surgery and incurable late-stage disease. The research is published this week in the Journal of Clinical Oncology.

“Unfortunately, distinguishing between independent primary tumors and metastasis is a frequent dilemma for pathologists,” [...]

Click here to view the rest of the post

Tags: biomarkers, cancer, Center for Individualized Medicine, DNA, DNA sequencing, dna test, DNA Testing, gene sequencing, genetic, Genetics, genome, genome science, Genome Sequencing, genomic, genomic medicine, genomics, independent primary tumors, Individualized Medicine, individualized Medicine clinic, IndividualizedMedicine, Lung Cancer, marie-christine aubry, Mayo Clinic, Me, metastasis, microbiome, personal genomics, personalized care, personalized medicine, predictive medicine, tumor, Tumors, whole genome sequencing

December 5th, 2014 · Leave a Comment

Realizing the Opportunities of Genomics in Health Care

By Center for Individualized Medicine

 

 

Speaking at the Individualizing Medicine Conference 2014, Geoffrey Ginsburg, M.D. discussed the opportunities for genetics in medicine around the areas of sequencing, data sharing, eMedicine and more.

Dr. Geoffrey Ginsburg is the founding director of the Center for Applied Genomics in the Duke University Medical Center and the founding executive director of the Center for Personalized and Precision Medicine in the Duke University Health System. He is a professor of medicine, pathology and biomedical engineering at Duke University.

 

 

________

Tags: biobank, biomarker, biomarkers, cancer, Center for Individualized Medicine, DNA, DNA sequencing, dna test, DNA Testing, gene sequencing, genetic, Genetics, genome science, Genome Sequencing, genomic medicine, genomics, Geoffrey Ginsberg, Individualized Medicine, individualized Medicine clinic, IndividualizedMedicine, Mayo Clinic, personal genomics, personalized care, personalized medicine, pharmacogenomics, predictive medicine, whole genome sequencing

December 3rd, 2014 · Leave a Comment

Diversity in Your Gut Influences Your Health

By Center for Individualized Medicine

 

PPI CIM Blog Header Image

 

Before reaching for that daily antacid, you might consider what it’s doing to the trillions of bugs living in your gut. A new Mayo Clinic study in the open access journal Microbiome shows that people who regularly take proton pump inhibitors (PPIs) have less diversity among their gut bacteria, putting them at increased risk for infections like clostridium difficile and pneumonia, in addition to vitamin deficiencies and bone fractures.

 
“Evidence has been mounting for years that long-term use of proton pump inhibitors poses increased risks for a variety of associated complications, but we have never really [...]

Click here to view the rest of the post

Tags: bacteria, biomarker, biomarkers, Center for Individualized Medicine, DNA sequencing, dna test, DNA Testing, gene sequencing, Genetics, genome, genome science, Genome Sequencing, genomic, genomic medicine, genomics, gut microbiome, Individualized Medicine, individualized Medicine clinic, IndividualizedMedicine, John DiBaise, Mayo Clinic, microbiome, nicholas chia, personal genomics, personalized care, personalized medicine, pharmacogenomics, predictive medicine, proton pump inhibitor, proton pump inhibitors, whole genome sequencing

November 25th, 2014 · Leave a Comment

Lessons From Disease Advocacy Organizations

By Richard Sharp, Ph.D.

 

Building A Legacy

 

The Cystic Fibrosis Foundation (CFF) recently announced that through the sale of the Foundation’s royalty rights to new therapies developed in collaboration with Vertex Pharmaceuticals Inc., they received $3.3 billion dollars.

This is an unprecedented amount of money to be raised by a disease advocacy organization through this type of transaction and highlights the success of the CFF over the past decade. Its efforts to develop new models of venture philanthropy in medical research showcase the power of patients and families partnering [...]

Click here to view the rest of the post

Tags: bioethics, Center for Individualized Medicine, CFF, Cystic Fibrosis Foundation, DNA, DNA sequencing, dna test, DNA Testing, gene sequencing, Genetics, genomic, genomic medicine, genomics, Individualized Medicine, IndividualizedMedicine, Mayo Clinic, personal genomics, personalized care, personalized medicine, predictive medicine, Richard Sharp, Vertex Pharmaceuticals, whole genome sequencing

November 13th, 2014 · Leave a Comment

Strand-Specific Analysis Shows Protein Binding at Replication Forks and PCNA Unloading from Lagging Strands when Forks Stall

By Center for Individualized Medicine

Zhiguo Publication

Zhiguo Zhang, Ph.D. and colleagues from the Center for Individualized Medicine, offer a new tool for genomic research, through a new method revealing genome-wide association of proteins with leading and lagging strands of DNA replication forks. This will provide a tool for studying the general replication-related processes and a specific mechanism that makes this possible.

 

Summary of Publication

In eukaryotic cells, DNA replication proceeds with continuous synthesis of leading-strand DNA and discontinuous synthesis of lagging-strand DNA. Here we describe a method, eSPAN (enrichment and sequencing of protein-associated nascent DNA), which reveals the genome-wide association of proteins with leading and lagging strands of DNA replication forks. [...]

Click here to view the rest of the post

Tags: Center for Individualized Medicine, DNA, DNA sequencing, dna test, DNA Testing, gene sequencing, genetic, Genetics, genome, genome science, Genome Sequencing, genomic, genomic medicine, genomics, Individualized Medicine, individualized Medicine clinic, IndividualizedMedicine, Mayo Clinic, personal genomics, personalized care, personalized medicine, predictive medicine, whole genome sequencing, Zhiguo Zhang

November 11th, 2014 · Leave a Comment

Individualizing Medicince 2014 Conference: Recap

By Center for Individualized Medicine

Individualizing Conference 2014 Recap

 

Quoting “the great poet from Hibbing, Minn.,” genomics pioneer Richard Weinshilboum, M.D., captured the spirit of the third annual Individualizing Medicine Conference 2014: From Promise to Practice when he invoked the legendary Bob Dylan. “‘The times they are a changin’,” Dr. Weinshilboum said.

The times are changing indeed. More than 750 physicians, researchers, scientists, medical staff, genetic counselors and others gathered in Rochester, Minn., to exchange ideas, engage in debate and hear the newest developments in genomics and individualized medicine.

No longer in the realm of science fiction, genomics has increasingly entered the mainstream of modern healthcare. But how [...]

Click here to view the rest of the post

Tags: biobank, bioethics, biomarker, biomarkers, cancer, Center for Individualized Medicine, DNA, DNA sequencing, dna test, DNA Testing, gene sequencing, genetic, Genetics, genome science, Genome Sequencing, genomic, genomic medicine, genomics, Gianrico Farrugia, Individualized Medicine, individualized Medicine clinic, IndividualizedMedicine, Mayo Clinic, microbiome, personal genomics, personalized care, personalized medicine, pharmacogenomics, predictive medicine, whole genome sequencing

Load More