October 23rd, 2014 · Leave a Comment

The Role of Ethics in Genomics

By Center for Individualized Medicine

 

 
Jen McCormick, Ph.D., director of the Bioethics Program for the Center for Individualized Medicine at Mayo Clinic explains the goal of the Bioethics Program, which is to ensure that the Center for Individualized Medicine is aware of and responsibly addressing the ethical, legal, policy and social issues related to genomic research, translating genomic technologies for clinical use and implementing genomic-based individualized medicine.
 
 
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Tags: bioethics, center for individualized medicine, DNA, DNA Sequencing, dna test, DNA Testing, gene sequencing, Genetics, genome, genome science, Genome Sequencing, genomic, genomic medicine, genomics, Individualized Medicine, individualized Medicine clinic, IndividualizedMedicine, Mayo Clinic, personal genomics, personalized care, personalized medicine, pharmacogenomics, predictive medicine, whole genome sequencing

October 21st, 2014 · Leave a Comment

Director of Pharmacogenomics Receives Honor From Mayo Clinic

By Center for Individualized Medicine

Richard Weinshilboum, M.D., Director of the Pharmacogenomics Program at the Center for Individualized Medicine, is being honored by the Mayo Clinic Board of Governors as a Mayo Clinic Distinguished Alumni. This is the highest award that Mayo can confer on its staff.

Dr. Weinshilboum studies pharmacogenomics — the role of inheritance and individual variation in DNA sequence or structure in drug response. The goal is to develop safer and more effective drug therapy to treat diseases that range from cancer to depression.

Dr. Weinshilboum's research program utilizes genomic techniques that include genome-wide association studies (GWAS) and "next-generation" whole genome DNA sequencing using samples from large numbers of patients treated with a specific anticancer [...]

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Tags: biomarkers, cancer, center for individualized medicine, DNA, DNA Sequencing, dna test, DNA Testing, Dr Richard Besser, gene sequencing, Genetics, genome, genome science, Genome Sequencing, genomic, genomic medicine, genomics, Individualized Medicine, Mayo Clinic, pharmacogenomics, predictive medicine, Weinshilboum, whole genome sequencing

October 15th, 2014 · Leave a Comment

Diet & Exercise Orthogonally Alter the Gut Microbiome

By Center for Individualized Medicine

New Research from the Epigenomics Program

 
And Reveal Independent Associations With Anxiety & Cognition
 

The Microbiome team at the Center for Inidivdualized Medicine of Mayo Clinic recently published a paper that found that ingestion of a high-fat diet (HFD) and the resulting obese state can exert a multitude of stressors on the individual including anxiety and cognitive dysfunction.

Though many studies have shown that exercise can alleviate the negative consequences of a HFD using metabolic readouts such as insulin and glucose, a paucity of well-controlled rodent studies have been published on HFD and exercise interactions with regard to behavioral outcomes. This is a critical issue since some [...]

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Tags: biomarker, biomarkers, center for individualized medicine, DNA, DNA Sequencing, dna test, DNA Testing, gene sequencing, genetic, Genetics, genome, genome science, Genome Sequencing, genomic, genomic medicine, genomics, Gut Microbiome, Individualized Medicine, Mayo Clinic, microbiome, personal genomics, personalized care, personalized medicine, predictive medicine, whole genome sequencing

October 14th, 2014 · Leave a Comment

A Mysterious Disease

By Center for Individualized Medicine

Jarvie Burdell

 

Article Originally found at Mayo Clinic's "You Are" Blog.

 

The genomic counselor brought good news — the Individualized Medicine Clinic team had found the culprit gene. Renata Burdell knew her son's medical odyssey was finally over.
"It has made such a huge difference," Renata says. "We don't have to keep wondering and going from one specialist to another looking for a reason for Javrie's symptoms."
In one sense, what she and her husband, Josiah Burdell, sought for their 6-year-old son, Javrie, was simple — a name for his condition. A seemingly endless parade of local caregivers failed to give [...]

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Tags: biobank, bioethics, biomarker, biomarkers, cancer, center for individualized medicine, DNA, DNA Sequencing, dna test, DNA Testing, gene sequencing, Genetics, genome, genome science, Genome Sequencing, genomic, genomic medicine, genomics, Individualized Medicine, individualized Medicine clinic, IndividualizedMedicine, Mayo Clinic, personal genomics, personalized care, personalized medicine, predictive medicine, whole genome sequencing

October 8th, 2014 · Leave a Comment

Individualizing Medicine 2014: Day Three Recap

By Sam Smith

The final day of the Individualizing Medicine 2014 Conference kicked off with one of the pioneers of genomics taking the stage. Having founded the Baylor College of Medicine Human Genome Sequencing Center in 1997, Richard Gibbs led one of the five main groups that completed the Human Genome Project. Gibbs discussed his past, present and future work at Baylor, and the impact clinical exome sequencing has had on genetic research. He has been active in Mendelian disease discovery, and discussed the limitations created by lack of sample size.

Munir Pirmohamed, M.B., Ch.B., Ph.D., the National Health Service Chair of Pharmacogenetics in the United Kingdom, presents his research on pharmacogenomics at Individualizing [...]</p/>
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Tags: Alexander Parker, Baylor College of Medicine, ceci connolly, Christopher Corless, Conference, DNA, EU-PACT, genome, genomics, Human Genome Sequencing Center, Individualized Medicine, Individualizing Medicine, individualizing medicine 2014, individualizing medicine conference, mayo clinic conference, Munir Pirmohamed, National Health Service, Peter Jones, Richard Gibbs, sequencing, Van Andel Institute

October 7th, 2014 · Leave a Comment

Individualizing Medicine 2014: Day Two Recap

By Sam Smith

Day two of the Individualizing Medicine 2014 Conference dispelled any notion of a conference on genomics being a gathering of humorless, stuffy scientists talking about the minutiae of genetic alphabet soup. Bob Dylan and Fifty Shades of Grey, Clint Eastwood and Dr. Seuss were intermixed in with informative talks that centered on the power of pharmacogenomics, the future, and challenges of the field.

Ceci Connolly, managing director of PwC's Health Research Institute, kicks off day two of Individualizing Medicine 2014: From Promise to Practice

Ceci Connolly, managing director of PwC's Health Research Institute, kicks off day two of Individualizing Medicine 2014: From Promise to Practice

Moderator Ceci Connolly introduced the [...]

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Tags: 23andMe, beauty project, ceci connolly, center for individualized medicine, Conference, dan roden, genomics, Gianrico Farrugia, im2014, Individualized Medicine, Individualized Medicine Conference, individualizing medicine 2014, individualizing medicine conference, Judy Boughey, lawrence lesko, lon cardon, Matthew Goetz, personalized medicine, rebecca nagy, Richard Weinshilboum, sequencing, tom petty

October 6th, 2014 · Leave a Comment

Individualizing Medicine 2014: Day One Recap

By Sam Smith

Gianrico Farrugia, M.D., Director of the Mayo Clinic Center for Individualized Medicine, took to the stage Monday morning to welcome nearly 500 attendees to the Individualizing Medicine 2014 Conference.  This third-annual genomics conference promises a practical approach to helping medical professionals discover and integrate genomics technology into routine patient care.
“We know we need to incorporate genomics into patient care. We have a moral obligation to bring genomics to the practice, and we have a moral obligation to do it right.”
—Gianrico Farrugia, M.D.
Clifford Hudis, M.D., immediate past president of the American Society of Clinical Oncology (ASCO), delivered the keynote address by challenging the participants to reexamine how we define value in cancer care. If the practitioners don’t, others will. He highlighted how the current [...]

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Tags: ASCO, biobank, Clifford Hudis, diana bianchi, duke, duke university, genomics, Gianrico Farrugia, gloria petersen, IM Conference, individualizing medicine conference, Mayo Clinic, patrick Geraghty, paul hergenrother, uiuc, university of illinois

October 5th, 2014 · Leave a Comment

Individualizing Medicine 2014: Pre-conference Session, The Physician's Odyssey

By Sam Smith

Mayo Clinic physician Timothy Curry and genomics scientist Matthew Ferber paired up to set the stage for the Individualizing Medicine 2014 Conference with opening remarks at the pre-conference session, an “Introduction to Genomic Medicine for Practitioners.”  They detailed how genomic medicine is now making the transition from technological marvel to bedside practice for physicians.

Timothy Curry, M.D., center, and Matthew Ferber, Ph.D., left, kickoff Individualizing Medicine 2014: From Promise to Practice at the Mayo Civic Center in Rochester, Minn.

Timothy Curry, M.D., center, and Matthew Ferber, Ph.D., left, kickoff Individualizing Medicine 2014: From Promise to Practice at the Mayo Civic Center in Rochester, Minn.

“Genomics isn’t just the future,” Dr. Curry said.  “Genomics [...]

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