November 25th, 2014 · Leave a Comment

Lessons From Disease Advocacy Organizations

By Richard Sharp, Ph.D.

 

Building A Legacy

 

The Cystic Fibrosis Foundation (CFF) recently announced that through the sale of the Foundation’s royalty rights to new therapies developed in collaboration with Vertex Pharmaceuticals Inc., they received $3.3 billion dollars.

This is an unprecedented amount of money to be raised by a disease advocacy organization through this type of transaction and highlights the success of the CFF over the past decade. Its efforts to develop new models of venture philanthropy in medical research showcase the power of patients and families partnering [...]

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Tags: bioethics, center for individualized medicine, CFF, Cystic Fibrosis Foundation, DNA, DNA sequencing, dna test, DNA Testing, gene sequencing, Genetics, genomic, genomic medicine, genomics, Individualized Medicine, IndividualizedMedicine, Mayo Clinic, personal genomics, personalized care, personalized medicine, predictive medicine, Richard Sharp, Vertex Pharmaceuticals, whole genome sequencing

November 13th, 2014 · Leave a Comment

Strand-Specific Analysis Shows Protein Binding at Replication Forks and PCNA Unloading from Lagging Strands when Forks Stall

By Center for Individualized Medicine

Zhiguo Publication

Zhiguo Zhang, Ph.D. and colleagues from the Center for Individualized Medicine, offer a new tool for genomic research, through a new method revealing genome-wide association of proteins with leading and lagging strands of DNA replication forks. This will provide a tool for studying the general replication-related processes and a specific mechanism that makes this possible.

 

Summary of Publication

In eukaryotic cells, DNA replication proceeds with continuous synthesis of leading-strand DNA and discontinuous synthesis of lagging-strand DNA. Here we describe a method, eSPAN (enrichment and sequencing of protein-associated nascent DNA), which reveals the genome-wide association of proteins with leading and lagging strands of DNA replication forks. [...]

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Tags: center for individualized medicine, DNA, DNA sequencing, dna test, DNA Testing, gene sequencing, genetic, Genetics, genome, genome science, Genome Sequencing, genomic, genomic medicine, genomics, Individualized Medicine, individualized Medicine clinic, IndividualizedMedicine, Mayo Clinic, personal genomics, personalized care, personalized medicine, predictive medicine, whole genome sequencing, Zhiguo Zhang

November 11th, 2014 · Leave a Comment

Individualizing Medicince 2014 Conference: Recap

By Center for Individualized Medicine

Individualizing Conference 2014 Recap

 

Quoting “the great poet from Hibbing, Minn.,” genomics pioneer Richard Weinshilboum, M.D., captured the spirit of the third annual Individualizing Medicine Conference 2014: From Promise to Practice when he invoked the legendary Bob Dylan. “‘The times they are a changin’,” Dr. Weinshilboum said.

The times are changing indeed. More than 750 physicians, researchers, scientists, medical staff, genetic counselors and others gathered in Rochester, Minn., to exchange ideas, engage in debate and hear the newest developments in genomics and individualized medicine.

No longer in the realm of science fiction, genomics has increasingly entered the mainstream of modern healthcare. But how [...]

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Tags: biobank, bioethics, biomarker, biomarkers, cancer, center for individualized medicine, DNA, DNA sequencing, dna test, DNA Testing, gene sequencing, genetic, Genetics, genome science, Genome Sequencing, genomic, genomic medicine, genomics, Gianrico Farrugia, Individualized Medicine, individualized Medicine clinic, IndividualizedMedicine, Mayo Clinic, microbiome, personal genomics, personalized care, personalized medicine, pharmacogenomics, predictive medicine, whole genome sequencing

November 6th, 2014 · Leave a Comment

Genetic Markers for Alcoholism Recovery Discovered at Mayo Clinic

By Center for Individualized Medicine

Genetic Markers for Alcoholism Recovery Discovered

 

Post originally featured on Mayo Clinic's News Network, written by Bob Nellis

 

In an international study, Mayo Clinic researchers and collaborators have identified genetic markers that may help in identifying individuals who could benefit from the alcoholism treatment drug acamprosate. The findings, published in the journal Translational Psychiatry, show that patients carrying these genetic variants have longer periods of abstinence during the first three months of acamprosate treatment.

Acamprosate is a commonly prescribed drug used to aid patients in recovery from alcoholism. Mayo researchers studied the association between variation in candidate genes and the length of sobriety [...]

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Tags: Alcoholism, Alcoholism Recovery, biomarker, biomarkers, center for individualized medicine, DNA sequencing, dna test, DNA Testing, gene sequencing, genetic, Genetics, genome, genome science, Genome Sequencing, genomic, genomic medicine, genomics, Individualized Medicine, individualized Medicine clinic, IndividualizedMedicine, Mayo Clinic, personal genomics, personalized care, personalized medicine, predictive medicine, whole genome sequencing

November 4th, 2014 · 1 Comment

Using Genomics to Treat Depression & Back Pain With the Right Drugs

By Center for Individualized Medicine

Mrazek Blog Post

In a recent USA Today article, Assurex Health was featured for their new tool to analyze patient DNA and, within 36 hours, return a report (through a secure portal) back to providers detailing which medications are most likely to be effective based on their genome. The test is called GeneSight and has been around for a few years, but until recently was only available through private insurers and out-of-pocket. Recent decisions from Medicare and the Department of Veterans Affairs to cover pharmacogenomic testing means that more people struggling with depression, bipolar disorder, and schizophrenia are likely to find the [...]

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Tags: Assurex, Assurex Health, center for individualized medicine, David Mrazek, DNA, DNA sequencing, dna test, DNA Testing, gene sequencing, Genetics, genome, genome science, Genome Sequencing, genomic, genomic medicine, genomics, Individualized Medicine, individualized Medicine clinic, Mayo Clinic, Mrazek, personal genomics, personalized care, personalized medicine, pharmacogenomics, predictive medicine, Psychiatric, Psychology, whole genome sequencing

October 30th, 2014 · Leave a Comment

The Future of Individualized Medicine at Mayo Clinic

By Center for Individualized Medicine

The Future of Individualized Medicine at Mayo Clinic

 

Individualizing Medicine 2014: From Promise to Practice, was held in October in Rochester, focusing on how to translate the promise of genomic medicine into practice. Expert speakers, focused breakout sessions, real-life case studies and a poster session provided attendees with many opportunities to discover and discuss emerging topics in applied genomics. Speakers covered a range of medical subjects, from cancer and rare diseases to cardiovascular medicine and obstetrics.

A few speakers below took time to answer some questions about how genomics is already transforming care at Mayo Clinic and what the future holds for this exciting [...]

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Tags: biobank, bioethics, biomarker, biomarkers, center for individualized medicine, DNA, DNA sequencing, dna test, DNA Testing, gene sequencing, genetic, Genetics, genome, genome science, Genome Sequencing, genomic, genomic medicine, genomics, Individualized Medicine, individualized Medicine clinic, IndividualizedMedicine, Judy Boughey, Kelly Wix, Matthew Goetz, Mayo Clinic, microbiome, personal genomics, personalized care, personalized medicine, pharmacogenomics, predictive medicine, whole genome sequencing

October 28th, 2014 · Leave a Comment

Findings Reveal Relationship with TP63 & p63 Protein Expression in Lung Adenocarcinoma

By Center for Individualized Medicine

 

New Research from the Epigenomics Program

 

Using next-generation sequencing analysis of mate-pair DNA libraries, a group of researchers from the Center for Individualized Medicine recently identified novel chromosomal rearrangements involving TP63 in approximately 6% in peripheral T-cell lymphomas and demonstrated that these were associated with a poorer overall survival than lymphomas without these rearrangements. These rearrangements also were found in occasional B-cell lymphomas, but were not identified by RNA sequencing in a small series of carcinomas of the lung, breast, or head and neck. By immunohistochemistry, TP63 rearrangements were associated with a p63+/p40− profile in lymphomas. As a subset of lung adenocarcinomas has a p63+/p40− [...]

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Tags: biobank, biomarker, biomarkers, cancer, center for individualized medicine, DNA, DNA sequencing, dna test, DNA Testing, gene sequencing, genetic, Genetics, genome, genome science, Genome Sequencing, genomic, genomic medicine, genomics, Individualized Medicine, individualized Medicine clinic, Mayo Clinic, microbiome, personal genomics, personalized care, predictive medicine, whole genome sequencing

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